Carrillo Francy Y E, Sanjuán Rafael, Moya Andrés, Cuevas José M
Institut Cavanilles de Biodiversitat i Biologia Evolutiva, Universitat de València, PO Box 22085, 46071 València, Spain.
Infect Genet Evol. 2007 Jan;7(1):69-73. doi: 10.1016/j.meegid.2006.04.004. Epub 2006 Jun 27.
In many infectious diseases, hosts are often simultaneously infected with several genotypes of the same pathogen. Much theoretical work has been done on modelling multiple infection dynamics, but empirical evidences are relatively scarce. Previous studies have demonstrated that coinfection allows faster adaptation than single infection in RNA viruses. Here, we use experimental populations of the vesicular stomatitis Indiana virus derived from an infectious cDNA, to show that superinfection dynamics promotes faster adaptation than single infection. In addition, we have analysed two different periodicities of multiple infection, daily and separated 5 days in time. Daily multiple infections allow higher fitness increases than multiple infections taking place every 5 days. We propose that the effect of superinfection on fitness is mainly influenced by the time elapsed between the first and the second infection, since shorter time intervals offer more opportunities to competition between resident and invading populations.
在许多传染病中，宿主常常同时感染同一种病原体的几种基因型。关于多重感染动态建模已经开展了大量理论研究，但实证证据相对较少。先前的研究表明，在RNA病毒中，共感染比单一感染能使适应速度更快。在此，我们使用源自感染性cDNA的水疱性口炎印第安纳病毒实验群体，以表明重叠感染动态比单一感染能促进更快的适应。此外，我们分析了多重感染的两种不同周期，即每天感染和间隔5天感染。每天的多重感染比每5天发生一次的多重感染能带来更高的适应性提升。我们提出，重叠感染对适应性的影响主要受首次感染和第二次感染之间的时间间隔影响，因为更短的时间间隔为驻留群体和入侵群体之间的竞争提供了更多机会。
