Aubertin-Leheudre Mylène, Audet Melisa, Goulet Eric D B, Dionne Isabelle J
Research Centre on Aging, University of Sherbrooke, 1036 Belvédère sud, Sherbrooke, Qué., Canada J1H 4C4.
Maturitas. 2005 Jun 16;51(2):140-5. doi: 10.1016/j.maturitas.2004.06.017.
Physical activity can prevent or retard the loss of muscle mass associated with aging. On the other hand, it has been suggested that HRT may also help prevent sarcopenia in postmenopausal women. We thus examined if HRT provides additional beneficial effect in physically active postmenopausal women.
Forty postmenopausal women aged between 55 and 65 years old (normal weight, healthy and no medication) were recruited. Seventeen women were already taking HRT for at least one year whereas 23 were never submitted to HRT. Body composition was measured by DXA and physical activity metabolism was obtained by the use of accelerometry. Subjects were divided in tertile groups based on their daily physical activity energy expenditure (PAEE).
Physical activity groups were similar for age, HRT users distribution, BMI, trunk fat-free mass (FFM), and all fat mass (FM) components. The group of women who were the most physically active significantly displayed greater total FFM, appendicular FFM, and muscle mass index (MMI) compared to the group of less active women (P < 0.05) whereas HRT added no additional effect on any FFM components.
Our results suggest that in active postmenopausal women, HRT does not provide any additional beneficial effect on body composition.
体育活动可预防或延缓与衰老相关的肌肉量流失。另一方面，有研究表明激素替代疗法（HRT）可能也有助于预防绝经后女性的肌肉减少症。因此，我们研究了HRT对身体活跃的绝经后女性是否具有额外的有益作用。
招募了40名年龄在55至65岁之间的绝经后女性（体重正常、身体健康且未服用药物）。其中17名女性已接受HRT治疗至少一年，而23名女性从未接受过HRT治疗。通过双能X线吸收法（DXA）测量身体成分，并使用加速度计获取身体活动代谢数据。根据每日身体活动能量消耗（PAEE）将受试者分为三分位数组。
各身体活动组在年龄、HRT使用者分布、体重指数（BMI）、躯干去脂体重（FFM）和所有脂肪量（FM）成分方面相似。与身体活动较少的女性组相比，身体活动最多的女性组的总FFM、四肢FFM和肌肉量指数（MMI）显著更高（P < 0.05），而HRT对任何FFM成分均未产生额外影响。
我们的研究结果表明，对于身体活跃的绝经后女性，HRT对身体成分没有任何额外的有益作用。
