Tokano Hisashi, Maehara Hirofumi, Nakamura Hiroko, Makino Nao, Iwasaki Akemi, Kitamura Ken
Department of Otolaryngology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Auris Nasus Larynx. 2005 Jun;32(2):145-50. doi: 10.1016/j.anl.2005.01.002. Epub 2005 Mar 23.
The aim of this study was to clarify the short-term effects of argon plasma coagulation (APC) of the inferior turbinate in patients with perennial nasal allergy. In a retrospective study, 32 patients with perennial allergic rhinitis were treated by inferior turbinate reduction using APC. Grades of nasal stuffiness, rhinorrhea, sneezing, nasal airflow resistance (NAR) and overall seriousness were evaluated before and then 1-4 and 8 weeks after APC. Subjective symptoms were assessed using a questionnaire in which nasal stuffiness, rhinorrhea and sneezing were graded on a four-point scale (severe, moderate, mild and none) using the Severity Criteria of Symptoms of Nasal Allergy issued by the Japanese Society of Allergology. NAR was measured using active anterior rhinomanometry (AAR) at the 100 Pa point; this was deemed to be an objective measurement of nasal obstruction. The numbers of patients examined before and 1-4 and 8 weeks after APC were 32, 31, 25, 17, 18 and 14, respectively. Both nasal stuffiness and NAR were significantly improved 2 weeks after APC, overall seriousness was significantly improved after 3 weeks and rhinorrhea was improved after 4 weeks. Sneezing did not significantly improve during this study. There was no significant change in the grades of the examined parameters during the period between 4 and 8 weeks after APC. The beneficial effects of APC begin to appear within 2 weeks after APC and no further improvement after about 4 weeks.
本研究的目的是阐明氩等离子体凝固术（APC）对常年性鼻过敏患者下鼻甲的短期影响。在一项回顾性研究中，32例常年性变应性鼻炎患者接受了APC下鼻甲缩小治疗。在APC治疗前、治疗后1 - 4周和8周评估鼻塞、流涕、打喷嚏、鼻气流阻力（NAR）及总体严重程度。主观症状采用问卷调查评估，其中鼻塞、流涕和打喷嚏根据日本变态反应学会发布的鼻过敏症状严重程度标准按四级评分（重度、中度、轻度和无）。使用主动前鼻测压法（AAR）在100 Pa点测量NAR；这被认为是鼻阻塞的客观测量方法。APC治疗前及治疗后1 - 4周和8周接受检查的患者人数分别为32、31、25、17、18和14例。APC治疗后2周鼻塞和NAR均显著改善，3周后总体严重程度显著改善，4周后流涕改善。在本研究期间打喷嚏未显著改善。APC治疗后4至8周期间，所检查参数的分级无显著变化。APC的有益效果在治疗后2周内开始显现，约4周后不再进一步改善。
