Orbak Zerrin
Atatürk University Faculty of Medicine, Department of Pediatric Endocrinology, Erzurum, Turkey.
J Trop Pediatr. 2005 Aug;51(4):216-8. doi: 10.1093/tropej/fmi001. Epub 2005 May 25.
Although there is knowledge about earlier mean age at menopause among left-handed postmenopausal women, it is unclear from the literature whether age of menarche is influenced by the prenatal hormonal pattern and cerebral lateralization. We therefore planned to investigate the relation between age of menarche and cerebral lateralization in girls at an altitude of nearly 2000 m. Sixty-two girls, aged between 9.4 and 15.5 years, were interviewed by questionnaire about manual dominance and menarcheal age. All girls were divided into two groups: left-handers (n = 31) and right-handers (n = 31). It was shown that there was a significantly lower average age of menarcheal appearance (12.96 +/- 1.34 years) in the left-handers' compared with the right-handers' (13.72 +/- 1.41 years; p = 0.025). The earliest menarcheal age was 9.4 years in left-handers and 10.1 years in right-handers.A menarcheal age of 13.34 +/- 1.35 years was found for the whole group at an altitude of nearly 2000 m. This data leads us to believe the existence of a link between functional brain asymmetry and menarche. It would appear that the activation of the hypothalamic-pituitary-gonadal axis is earlier in left-handed females than in right-handed females.
虽然已知绝经后左撇子女性的平均绝经年龄较早，但从文献中尚不清楚初潮年龄是否受产前激素模式和大脑偏侧化的影响。因此，我们计划调查海拔近2000米地区女孩的初潮年龄与大脑偏侧化之间的关系。通过问卷调查了62名年龄在9.4至15.5岁之间的女孩的用手习惯和初潮年龄。所有女孩被分为两组：左撇子组（n = 31）和右撇子组（n = 31）。结果显示，左撇子女孩的平均初潮年龄（12.96 +/- 1.34岁）显著低于右撇子女孩（13.72 +/- 1.41岁；p = 0.025）。左撇子女孩最早的初潮年龄为9.4岁，右撇子女孩为10.1岁。在海拔近2000米的整个研究组中，初潮年龄为13.34 +/- 1.35岁。这些数据使我们相信大脑功能不对称与初潮之间存在联系。似乎左撇子女性下丘脑 - 垂体 - 性腺轴的激活比右撇子女性更早。
