Nikolova P, Stoyanov Z, Negrev N
Department of Physiology, Medical University Varna, Bulgaria.
Int J Psychophysiol. 1994 Dec;18(3):213-5. doi: 10.1016/0167-8760(94)90007-8.
Functional brain asymmetry influences many functions of the organism; the neuroendocrine axis is one that has received insufficient attention. In this study we set us as the goal of studying the link between functional brain asymmetry and menarcheal age in females with left versus right manual dominance. The appearance of the first menarche was used as a natural model of functioning of the hypothalamic-pituitary-gonadal (HPG) axis. 1695 females, aged between 16 and 25 years, were interviewed by questionnaire about manual dominance and menarcheal age. 182 women were selected and divided into 2 groups: all left-handers (n = 91), and a control group of 91 right-handers. We found a significantly lower average age of menarcheal appearance in the left-handers' age of 12.09 +/- 0.16 years compared to the right-handers' age of 13.32 +/- 0.12 years (p < 0.001). The earliest menarcheal age in left-handers was 8 years and the peak of appearance at age 13 (in 30.76% of the cases). In right-handers these values were 10 and 14 years (in 40.60% of the cases), respectively. The data allow us to accept the existence of a link between functional brain asymmetry and menarche, which causes earlier activation of the HPG axis in left-handed females.
大脑功能不对称影响机体的许多功能；神经内分泌轴就是其中一个未得到充分关注的方面。在本研究中，我们将研究左利手与右利手女性大脑功能不对称与初潮年龄之间的联系作为目标。初潮的出现被用作下丘脑 - 垂体 - 性腺（HPG）轴功能的自然模型。通过问卷调查对1695名年龄在16至25岁之间的女性询问其利手情况和初潮年龄。选取182名女性并分为两组：所有左利手者（n = 91），以及91名右利手者组成的对照组。我们发现，左利手者初潮出现的平均年龄显著低于右利手者，分别为12.09 +/- 0.16岁和13.32 +/- 0.12岁（p < 0.001）。左利手者最早初潮年龄为8岁，13岁时出现初潮的峰值（占30.76%的病例）。在右利手者中，这些值分别为10岁和14岁（占40.60%的病例）。这些数据使我们能够接受大脑功能不对称与初潮之间存在联系，这种联系导致左利手女性的HPG轴更早激活。
