Asayama Kei, Ohkubo Takayoshi, Kikuya Masahiro, Metoki Hirohito, Obara Taku, Hoshi Haruhisa, Hashimoto Junichiro, Totsune Kazuhito, Satoh Hiroshi, Imai Yutaka
Department of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences and Medicine, 1-1 Seiryo-cho, Aoba-ku, Sendai 980-8574, Japan.
Eur Heart J. 2005 Oct;26(19):2026-31. doi: 10.1093/eurheartj/ehi330. Epub 2005 May 25.
To evaluate the predictive power of the risk stratification system proposed in the 2003 European Society of Hypertension-European Society of Cardiology (2003 ESH-ESC) guidelines and to compare self-measured blood pressure at home (HBP) with casual-screening blood pressure (CBP) for prediction of first stroke among a general Japanese population.
HBP and CBP were measured in 1702 subjects (> or = 40 years) who had no history of stroke and who were followed for an average of 11 years. The subjects were assigned to one of five groups with differential risk stratification according to the 2003 ESH-ESC criteria: average risk, low added risk, moderate added risk, high added risk, and very high added risk. Even in the low risk group a significantly high risk for stroke was observed, and there was a linear step up of stroke risk based on HBP, as well as on CBP. On the basis of HBP classification, a higher stroke incidence was observed in the high and very high groups compared with CBP classification.
The risk stratification system proposed in the 2003 ESH-ESC guidelines is valid for the prediction of stroke in this Japanese study population, and has a stronger predictive power when based on HBP than on CBP. The results indicate the usefulness of HBP for the prediction of stroke risk in individuals.
评估2003年欧洲高血压学会-欧洲心脏病学会(2003 ESH-ESC)指南中提出的风险分层系统的预测能力,并比较日本普通人群中家庭自测血压(HBP)与随机筛查血压(CBP)对首次中风的预测作用。
对1702名无中风病史且平均随访11年的受试者(年龄≥40岁)测量了HBP和CBP。根据2003 ESH-ESC标准,将受试者分为五个风险分层不同的组:平均风险、低额外风险、中额外风险、高额外风险和非常高额外风险。即使在低风险组中,也观察到显著的高中风风险,并且基于HBP以及CBP的中风风险呈线性上升。基于HBP分类,与CBP分类相比,高风险和非常高风险组的中风发病率更高。
2003 ESH-ESC指南中提出的风险分层系统在本日本研究人群中对中风预测是有效的,并且基于HBP时比基于CBP具有更强的预测能力。结果表明HBP对个体中风风险预测的有用性。