Greene L, Brundage W, Cooper K
Department of Pathology, University of Vermont and Fletcher Allen Health Care, Smith 2, Pathology, 111 Colchester Avenue, Burlington, VT 05401, USA.
J Clin Pathol. 2005 Jun;58(6):658-61. doi: 10.1136/jcp.2004.019927.
This report describes a case of large cell neuroendocrine carcinoma (LCNEC) of the larynx. A 74 year old man who presented with otalgia underwent direct laryngoscopy with biopsy, which revealed an invasive poorly differentiated carcinoma. Laryngectomy with bilateral neck dissections revealed invasion of the pre-epiglottic space by the tumour, with metastases to bilateral lymph nodes (AJCC T3N2c). The tumour was characterised by large cells with vesicular chromatin and prominent nucleoli. The cells were arranged in organoid and trabecular patterns with a background of extensive necrosis and numerous mitotic figures. Immunohistochemical and ultrastructural analyses confirmed the neuroendocrine nature of the tumour. Metastatic disease was present in the liver, and the patient died within weeks of surgery. LCNEC carcinoma is a rare tumour of the larynx. Recognition at this site is essential so that proper patient management can be initiated.
本报告描述了一例喉大细胞神经内分泌癌（LCNEC）。一名74岁男性因耳痛就诊，接受了直接喉镜检查及活检，结果显示为浸润性低分化癌。喉切除术加双侧颈部淋巴结清扫显示肿瘤侵犯会厌前间隙，并伴有双侧淋巴结转移（美国癌症联合委员会T3N2c）。肿瘤的特征为具有泡状染色质和明显核仁的大细胞。细胞呈器官样和小梁状排列，伴有广泛坏死背景和大量有丝分裂象。免疫组化和超微结构分析证实了肿瘤的神经内分泌性质。肝脏出现转移性病变，患者在手术后数周内死亡。LCNEC癌是一种罕见的喉肿瘤。在此部位识别该肿瘤至关重要，以便能够启动恰当的患者管理。
