柑橘素1.1对引起皮肤和软组织感染的革兰氏阳性病原体的体外活性及杀伤作用。
In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections.
作者信息
Giacometti Andrea, Cirioni Oscar, Kamysz Wojciech, Silvestri Carmela, Del Prete Maria Simona, Licci Alberto, D'Amato Giuseppina, Łukasiak Jerzy, Scalise Giorgio
机构信息
Institute of Infectious Diseases and Public Health, c/o Ospedale Regionale, via Conca, 71, Ancona, I-60020, Italy.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2507-9. doi: 10.1128/AAC.49.6.2507-2509.2005.
Abstract
The in vitro activity of citropin 1.1 against gram-positive cocci was measured by MIC, minimal bactericidal concentration, time-kill studies, and a checkerboard titration method. Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline.
摘要
通过最小抑菌浓度（MIC）、最低杀菌浓度、时间-杀菌研究以及棋盘滴定法测定了柑橘肽1.1对革兰氏阳性球菌的体外活性。链球菌和葡萄球菌分别在1至16毫克/升的浓度下受到抑制。肠球菌的敏感性较低。当柑橘肽1.1与克拉霉素和强力霉素联合使用时显示出协同作用。
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