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2
Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia.替加环素（GAR-936）对嗜肺军团菌的体外活性以及在豚鼠嗜肺军团菌肺炎模型中的活性。
Antimicrob Agents Chemother. 2003 Feb;47(2):533-40. doi: 10.1128/AAC.47.2.533-540.2003.
3
In-vitro activity of levofloxacin against clinical isolates of Legionella spp, its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia.左氧氟沙星对嗜肺军团菌临床分离株的体外活性、在豚鼠体内的药代动力学及其在实验性嗜肺军团菌肺炎中的应用。
J Antimicrob Chemother. 1996 Jan;37(1):117-26. doi: 10.1093/jac/37.1.117.
4
Comparison of three buffers used in the formulation of buffered charcoal yeast extract medium.用于配制缓冲活性炭酵母提取物培养基的三种缓冲液的比较。
J Clin Microbiol. 1993 Dec;31(12):3329-30. doi: 10.1128/jcm.31.12.3329-3330.1993.
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Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.军团菌病细菌（嗜肺军团菌）在人类单核细胞内进行细胞内增殖。
J Clin Invest. 1980 Sep;66(3):441-50. doi: 10.1172/JCI109874.
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WIN 57273 is bactericidal for Legionella pneumophila grown in alveolar macrophages.WIN 57273 对在肺泡巨噬细胞中生长的嗜肺军团菌具有杀菌作用。
Antimicrob Agents Chemother. 1989 Dec;33(12):2132-6. doi: 10.1128/AAC.33.12.2132.
7
In vitro activity of azithromycin against clinical isolates of Legionella species.阿奇霉素对嗜肺军团菌临床分离株的体外活性
Antimicrob Agents Chemother. 1991 Jan;35(1):180-1. doi: 10.1128/AAC.35.1.180.

LBM415（NVP PDF - 713）对嗜肺军团菌的体外及细胞内活性

In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila.

作者信息

Edelstein Paul H, Hu Baofeng, Edelstein Martha A C

机构信息

Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2533-5. doi: 10.1128/AAC.49.6.2533-2535.2005.

DOI:10.1128/AAC.49.6.2533-2535.2005
PMID:15917565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140506/
Abstract

LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC50 for 20 Legionella sp. strains was 4 microg/ml, versus 0.06, 0.25, and <or=0.03 microg/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 microg/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.

摘要

研究了LBM415对细胞外和细胞内嗜肺军团菌的活性。LBM415对20株军团菌属菌株的MIC50为4微克/毫升，而阿奇霉素、红霉素和左氧氟沙星的MIC50分别为0.06、0.25和≤0.03微克/毫升。LBM415（0.5和16微克/毫升）可可逆地阻止两株嗜肺军团菌的细胞内生长，且活性低于红霉素。