LBM415（NVP PDF - 713）对嗜肺军团菌的体外及细胞内活性
In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila.
作者信息
Edelstein Paul H, Hu Baofeng, Edelstein Martha A C
机构信息
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and Clinical Microbiology Laboratory, Hospital of the University of Pennsylvania, Philadelphia, PA 19104-4283, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2533-5. doi: 10.1128/AAC.49.6.2533-2535.2005.
Abstract
LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC50 for 20 Legionella sp. strains was 4 microg/ml, versus 0.06, 0.25, and <or=0.03 microg/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 microg/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.
摘要
研究了LBM415对细胞外和细胞内嗜肺军团菌的活性。LBM415对20株军团菌属菌株的MIC50为4微克/毫升，而阿奇霉素、红霉素和左氧氟沙星的MIC50分别为0.06、0.25和≤0.03微克/毫升。LBM415（0.5和16微克/毫升）可可逆地阻止两株嗜肺军团菌的细胞内生长，且活性低于红霉素。
相似文献
1
In vitro and intracellular activities of LBM415 (NVP PDF-713) against Legionella pneumophila.LBM415（NVP PDF - 713）对嗜肺军团菌的体外及细胞内活性
Antimicrob Agents Chemother. 2005 Jun;49(6):2533-5. doi: 10.1128/AAC.49.6.2533-2535.2005.
2
Review of azithromycin activity against Legionella spp.阿奇霉素对军团菌属活性的综述
Pathol Biol (Paris). 1995 Jun;43(6):569-72.
3
In vitro activity of gemifloxacin (SB-265805, LB20304a) against Legionella pneumophila and its pharmacokinetics in guinea pigs with L. pneumophila pneumonia.吉米沙星（SB - 265805，LB20304a）对嗜肺军团菌的体外活性及其在嗜肺军团菌肺炎豚鼠体内的药代动力学。
Antimicrob Agents Chemother. 2001 Aug;45(8):2204-9. doi: 10.1128/AAC.45.8.2204-2209.2001.
4
In vitro activity of ABT-773 against Legionella pneumophila, its pharmacokinetics in guinea pigs, and its use to treat guinea pigs with L. pneumophila pneumonia.ABT-773对嗜肺军团菌的体外活性、在豚鼠体内的药代动力学及其用于治疗嗜肺军团菌肺炎豚鼠的研究
Antimicrob Agents Chemother. 2001 Oct;45(10):2685-90. doi: 10.1128/AAC.45.10.2685-2690.2001.
5
In vitro and in vivo activity of olamufloxacin (HSR-903) against Legionella spp.奥马沙星（HSR-903）对军团菌属的体外和体内活性
J Antimicrob Chemother. 2003 Dec;52(6):920-4. doi: 10.1093/jac/dkh001. Epub 2003 Nov 12.
6
In vitro activity of the ketolide HMR 3647 (RU 6647) for Legionella spp., its pharmacokinetics in guinea pigs, and use of the drug to treat guinea pigs with Legionella pneumophila pneumonia.酮内酯类药物HMR 3647（RU 6647）对军团菌属的体外活性、在豚鼠体内的药代动力学以及该药物用于治疗豚鼠嗜肺军团菌肺炎的研究
Antimicrob Agents Chemother. 1999 Jan;43(1):90-5. doi: 10.1128/AAC.43.1.90.
7
BMS-284756 (T-3811ME) a new fluoroquinolone: in vitro activity against Legionella, efficacy in a guinea pig model of L. pneumophila pneumonia and pharmacokinetics in guinea pigs.BMS-284756（T-3811ME）一种新型氟喹诺酮类药物：对军团菌的体外活性、在豚鼠嗜肺军团菌肺炎模型中的疗效以及豚鼠体内药代动力学
J Antimicrob Chemother. 2001 Nov;48(5):667-75. doi: 10.1093/jac/48.5.667.
8
9
Activity of iclaprim against Legionella pneumophila.依拉普明对嗜肺军团菌的活性。
J Antimicrob Chemother. 2007 Oct;60(4):905-6. doi: 10.1093/jac/dkm288. Epub 2007 Aug 6.
10
Comparative activity of quinolones, macrolides and ketolides against Legionella species using in vitro broth dilution and intracellular susceptibility testing.使用体外肉汤稀释法和细胞内药敏试验比较喹诺酮类、大环内酯类和酮内酯类对军团菌属的活性。
Int J Antimicrob Agents. 2005 Apr;25(4):302-7. doi: 10.1016/j.ijantimicag.2004.08.019.
引用本文的文献
1
Drug forecast - the peptide deformylase inhibitors as antibacterial agents.药物预测——肽酰基转移酶抑制剂作为抗菌剂。
Ther Clin Risk Manag. 2007 Aug;3(4):513-25.
2
Activity of LBM415 compared to those of 11 other agents against Haemophilus species.与其他11种药物相比，LBM415对嗜血杆菌属的活性。
Antimicrob Agents Chemother. 2006 Jul;50(7):2323-9. doi: 10.1128/AAC.00106-06.
本文引用的文献
1
Potential utility of a peptide deformylase inhibitor (NVP PDF-713) against oxazolidinone-resistant or streptogramin-resistant Gram-positive organism isolates.一种肽脱甲酰基酶抑制剂（NVP PDF - 713）对耐恶唑烷酮或耐链阳菌素革兰氏阳性菌分离株的潜在效用。
J Antimicrob Chemother. 2004 May;53(5):804-7. doi: 10.1093/jac/dkh184. Epub 2004 Mar 31.
2
Activities of tigecycline (GAR-936) against Legionella pneumophila in vitro and in guinea pigs with L. pneumophila pneumonia.替加环素（GAR-936）对嗜肺军团菌的体外活性以及在豚鼠嗜肺军团菌肺炎模型中的活性。
Antimicrob Agents Chemother. 2003 Feb;47(2):533-40. doi: 10.1128/AAC.47.2.533-540.2003.
3
In-vitro activity of levofloxacin against clinical isolates of Legionella spp, its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia.左氧氟沙星对嗜肺军团菌临床分离株的体外活性、在豚鼠体内的药代动力学及其在实验性嗜肺军团菌肺炎中的应用。
J Antimicrob Chemother. 1996 Jan;37(1):117-26. doi: 10.1093/jac/37.1.117.
4
Comparison of three buffers used in the formulation of buffered charcoal yeast extract medium.用于配制缓冲活性炭酵母提取物培养基的三种缓冲液的比较。
J Clin Microbiol. 1993 Dec;31(12):3329-30. doi: 10.1128/jcm.31.12.3329-3330.1993.
5
Legionnaires' disease bacterium (Legionella pneumophila) multiples intracellularly in human monocytes.军团菌病细菌（嗜肺军团菌）在人类单核细胞内进行细胞内增殖。
J Clin Invest. 1980 Sep;66(3):441-50. doi: 10.1172/JCI109874.
6
WIN 57273 is bactericidal for Legionella pneumophila grown in alveolar macrophages.WIN 57273 对在肺泡巨噬细胞中生长的嗜肺军团菌具有杀菌作用。
Antimicrob Agents Chemother. 1989 Dec;33(12):2132-6. doi: 10.1128/AAC.33.12.2132.
7
In vitro activity of azithromycin against clinical isolates of Legionella species.阿奇霉素对嗜肺军团菌临床分离株的体外活性
Antimicrob Agents Chemother. 1991 Jan;35(1):180-1. doi: 10.1128/AAC.35.1.180.
Zotero 插件