Edelstein P H
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA.
Pathol Biol (Paris). 1995 Jun;43(6):569-72.
Azithromycin is about as active against Legionella spp. in vitro as is erythromycin, with modal MICs approximately 0.5 to 0.125 microgram/ml, depending on the method used. In contrast, azithromycin is much more active against intracellular L. pneumophila than is erythromycin. In a guinea pig model of Legionnaires' disease, azithromycin is much more active than is erythromycin or clarithromycin. Despite the paucity of reports of treatment of Legionnaires' disease with azithromycin, it is likely to be as or more effective than erythromycin.
阿奇霉素在体外对军团菌属的活性与红霉素相当，其最低抑菌浓度（MIC）通常约为0.5至0.125微克/毫升，具体取决于所使用的方法。相比之下，阿奇霉素对细胞内嗜肺军团菌的活性比红霉素强得多。在豚鼠军团病模型中，阿奇霉素的活性比红霉素或克拉霉素强得多。尽管关于用阿奇霉素治疗军团病的报道较少，但它可能与红霉素一样有效或更有效。
