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阿奇霉素对嗜肺军团菌临床分离株的体外活性

In vitro activity of azithromycin against clinical isolates of Legionella species.

作者信息

Edelstein P H, Edelstein M A

机构信息

Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.

出版信息

Antimicrob Agents Chemother. 1991 Jan;35(1):180-1. doi: 10.1128/AAC.35.1.180.

DOI:10.1128/AAC.35.1.180
PMID:1849708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC244963/
Abstract

The activities of azithromycin, erythromycin, and ciprofloxacin against 21 Legionella isolates were measured by an agar dilution method and in macrophages. The MICs for 90% of strains tested were 2.0, 1.0, and 0.5 micrograms/ml for azithromycin, erythromycin, and ciprofloxacin, respectively. Azithromycin and ciprofloxacin were both bactericidal in the macrophage system, but erythromycin was bacteriostatic.

摘要

采用琼脂稀释法并在巨噬细胞中测定了阿奇霉素、红霉素和环丙沙星对21株嗜肺军团菌分离株的活性。阿奇霉素、红霉素和环丙沙星对90%受试菌株的最低抑菌浓度（MIC）分别为2.0、1.0和0.5微克/毫升。在巨噬细胞系统中，阿奇霉素和环丙沙星均具有杀菌作用，但红霉素具有抑菌作用。

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本文引用的文献

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Activities of amikacin, roxithromycin, and azithromycin alone or in combination with tumor necrosis factor against Mycobacterium avium complex.阿米卡星、罗红霉素和阿奇霉素单独或与肿瘤坏死因子联合应用对鸟分枝杆菌复合群的活性。
Antimicrob Agents Chemother. 1988 Aug;32(8):1149-53. doi: 10.1128/AAC.32.8.1149.
2
Azithromycin, a macrolide antibiotic with potent activity against Toxoplasma gondii.阿奇霉素，一种对弓形虫具有强效活性的大环内酯类抗生素。
Antimicrob Agents Chemother. 1988 May;32(5):755-7. doi: 10.1128/AAC.32.5.755.
3
WIN 57273 is bactericidal for Legionella pneumophila grown in alveolar macrophages.WIN 57273 对在肺泡巨噬细胞中生长的嗜肺军团菌具有杀菌作用。
Antimicrob Agents Chemother. 1989 Dec;33(12):2132-6. doi: 10.1128/AAC.33.12.2132.
4
In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection.吞噬细胞对阿奇霉素（CP-62,993）的体外和体内摄取：感染部位递送和释放的可能机制。
Antimicrob Agents Chemother. 1989 Mar;33(3):277-82. doi: 10.1128/AAC.33.3.277.
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Spectrum and mode of action of azithromycin (CP-62,993), a new 15-membered-ring macrolide with improved potency against gram-negative organisms.阿奇霉素（CP - 62,993）的抗菌谱及作用方式，一种对革兰氏阴性菌效力增强的新型15元环大环内酯类抗生素。
Antimicrob Agents Chemother. 1987 Dec;31(12):1939-47. doi: 10.1128/AAC.31.12.1939.
6
The pharmacokinetics of azithromycin in human serum and tissues.阿奇霉素在人血清和组织中的药代动力学。
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