阿奇霉素对嗜肺军团菌临床分离株的体外活性
In vitro activity of azithromycin against clinical isolates of Legionella species.
作者信息
Edelstein P H, Edelstein M A
机构信息
Department of Pathology, University of Pennsylvania, School of Medicine, Philadelphia 19104-4283.
出版信息
Antimicrob Agents Chemother. 1991 Jan;35(1):180-1. doi: 10.1128/AAC.35.1.180.
Abstract
The activities of azithromycin, erythromycin, and ciprofloxacin against 21 Legionella isolates were measured by an agar dilution method and in macrophages. The MICs for 90% of strains tested were 2.0, 1.0, and 0.5 micrograms/ml for azithromycin, erythromycin, and ciprofloxacin, respectively. Azithromycin and ciprofloxacin were both bactericidal in the macrophage system, but erythromycin was bacteriostatic.
摘要
采用琼脂稀释法并在巨噬细胞中测定了阿奇霉素、红霉素和环丙沙星对21株嗜肺军团菌分离株的活性。阿奇霉素、红霉素和环丙沙星对90%受试菌株的最低抑菌浓度（MIC）分别为2.0、1.0和0.5微克/毫升。在巨噬细胞系统中，阿奇霉素和环丙沙星均具有杀菌作用，但红霉素具有抑菌作用。
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