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Clin Infect Dis. 2004 Mar 1;38(5):670-7. doi: 10.1086/381550. Epub 2004 Feb 17.
2
A new member of the tripartite multidrug efflux pumps, MexVW-OprM, in Pseudomonas aeruginosa.铜绿假单胞菌中三重多药外排泵MexVW - OprM的一个新成员。
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Clin Infect Dis. 2002 Apr 15;34(8):1047-54. doi: 10.1086/339488. Epub 2002 Mar 15.
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铜绿假单胞菌临床分离株暴露于环丙沙星或头孢吡肟后交叉耐药性的选择。

Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.

作者信息

Alyaseen Samer A, Piper Kerryl E, Rouse Mark S, Steckelberg James M, Patel Robin

机构信息

Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine, 200 First St. SW, Rochester, MN 55905, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2543-5. doi: 10.1128/AAC.49.6.2543-2545.2005.

DOI:10.1128/AAC.49.6.2543-2545.2005
PMID:15917569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1140511/
Abstract

Exposure of ciprofloxacin- and cefepime-susceptible Pseudomonas aeruginosa isolates to increasing concentrations of ciprofloxacin selected for ciprofloxacin resistance in 26/27 and cefepime nonsusceptibility in 7/27 isolates. Exposure of the isolates to increasing concentrations of cefepime selected for cefepime nonsusceptibility in 20/27 isolates but not for ciprofloxacin resistance.

摘要

将对环丙沙星和头孢吡肟敏感的铜绿假单胞菌分离株暴露于浓度不断增加的环丙沙星中，在27株中有26株产生了环丙沙星耐药性，在27株中有7株产生了头孢吡肟不敏感性。将这些分离株暴露于浓度不断增加的头孢吡肟中，在27株中有20株产生了头孢吡肟不敏感性，但未产生环丙沙星耐药性。