Peña C, Suarez C, Tubau F, Dominguez A, Sora M, Pujol M, Gudiol F, Ariza J
IDIBELL, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
Eur J Clin Microbiol Infect Dis. 2009 May;28(5):519-22. doi: 10.1007/s10096-008-0645-9. Epub 2008 Oct 24.
A cohort study was carried out on hospitalized adult non-critically ill patients (January 2003-December 2004) to identify factors associated with the acquisition of multidrug-resistant Pseudomonas aeruginosa (MDR-PA). A total of 246 non-critically patients were included, 162 (66%) who revealed MDR-PA in the first isolate and 84 (34%) who had carbapenem-resistant P. aeruginosa (CR-PA) isolates. Multivariate analysis identified nosocomial acquisition (odds ratio [OR] 2.7, 95% confidence interval [CI] 1.1-6.3), urinary catheter (OR 2.1, 95%CI 1.1-4.3), and the prior use of fluoroquinolones (OR 2.6, 95%CI 1.0-6.7) as independent risk factors associated with MDR-PA acquisition. Our results show that antibiotics, most notably, fluoroquinolones, may play a major role in the emergence of MDR-PA.
对2003年1月至2004年12月期间住院的成年非危重症患者进行了一项队列研究，以确定与获得多重耐药铜绿假单胞菌（MDR-PA）相关的因素。总共纳入了246例非危重症患者，其中162例（66%）首次分离出MDR-PA，84例（34%）分离出耐碳青霉烯类铜绿假单胞菌（CR-PA）。多变量分析确定医院获得感染（比值比[OR]2.7，95%置信区间[CI]1.1-6.3）、导尿管（OR 2.1，95%CI 1.1-4.3）以及先前使用氟喹诺酮类药物（OR 2.6，95%CI 1.0-6.7）是与获得MDR-PA相关的独立危险因素。我们的结果表明，抗生素，尤其是氟喹诺酮类药物，可能在MDR-PA的出现中起主要作用。
