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美国流感嗜血杆菌呼吸道分离株中β-内酰胺酶产生率的下降

Decreasing prevalence of beta-lactamase production among respiratory tract isolates of Haemophilus influenzae in the United States.

作者信息

Heilmann Kris P, Rice Cassie L, Miller Ashley L, Miller Norma J, Beekmann Susan E, Pfaller Michael A, Richter Sandra S, Doern Gary V

机构信息

Division of Medical Microbiology, Department of Pathology, Roy J. and Lucille A. Carver University of Iowa College of Medicine, Iowa City, IA 52242, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jun;49(6):2561-4. doi: 10.1128/AAC.49.6.2561-2564.2005.

Abstract

A total of 986 isolates of Haemophilus influenzae from patients with respiratory tract infections in 45 United States medical centers were characterized during the winter of 2002-2003. beta-Lactamase production was noted with 26.2% of isolates; 14.6% were resistant to trimethoprim-sulfamethoxazole. Resistance to other relevant antimicrobial agents was extremely uncommon. In comparison to the results of four previous national surveys conducted since 1994, the prevalence of beta-lactamase production with this pathogen appears to be decreasing.

摘要

2002年至2003年冬季,对美国45个医疗中心呼吸道感染患者的986株流感嗜血杆菌进行了特征分析。26.2%的分离株产生β-内酰胺酶;14.6%对甲氧苄啶-磺胺甲恶唑耐药。对其他相关抗菌药物的耐药情况极为罕见。与1994年以来进行的四项全国性调查结果相比,该病原体产生β-内酰胺酶的患病率似乎在下降。

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