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一名儿科患者的 A 型流感嗜血杆菌(Hia)脑膜炎治疗:病例报告

Treatment of Haemophilus influenzae Serotype A (Hia) Meningitis in a Pediatric Patient: A Case Report.

作者信息

Thomas Matthew, Patel Shivang, Kambhampati Harthik, Thomas Miriam

机构信息

Pediatrics and Child Health, Lake Erie College of Osteopathic Medicine, Bradenton, USA.

College of Medicine, Lake Erie College of Osteopathic Medicine, Bradenton, USA.

出版信息

Cureus. 2025 Mar 8;17(3):e80253. doi: 10.7759/cureus.80253. eCollection 2025 Mar.

Abstract

serotype A (Hia) meningitis is a rare but severe pediatric infection, with significant risks of mortality and long-term complications. Here, we describe a 10-week-old male presenting with Hia meningitis complicated by cerebritis, seizures, and central venous catheter-related deep vein thrombosis (CADVT). The patient initially presented with fever, irritability, and feeding difficulties and was later found to have significant laboratory abnormalities and cerebrospinal fluid (CSF) findings suggestive of bacterial meningitis. This case highlights the empiric treatment of pediatric meningitis, tailored and adjunctive treatments based on culture results, and other thrombotic and neurological complications. Despite high morbidity risks, the patient demonstrated complete clinical recovery at two years and showed no signs of long-term sequelae. This case emphasizes the evolving epidemiology of Hia and the importance of timely diagnosis and multidisciplinary management in severe pediatric infections, to ensure the minimization of negative externalities.

摘要

A 群(Hia)脑膜炎是一种罕见但严重的儿科感染性疾病,具有显著的死亡风险和长期并发症风险。在此,我们描述一名 10 周大的男性患儿,其患有 A 群(Hia)脑膜炎,并伴有脑炎、癫痫发作以及与中心静脉导管相关的深静脉血栓形成(CADVT)。该患者最初表现为发热、烦躁和喂养困难,随后发现有明显的实验室异常以及脑脊液(CSF)检查结果提示细菌性脑膜炎。本病例突出了小儿脑膜炎的经验性治疗、基于培养结果的针对性和辅助性治疗,以及其他血栓形成和神经并发症。尽管存在高发病风险,但该患者在两年时实现了完全临床康复,且未表现出长期后遗症的迹象。本病例强调了 A 群(Hia)不断演变的流行病学特征,以及在严重儿科感染中及时诊断和多学科管理的重要性,以确保将负面外部效应降至最低。

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Virchow's triad in "silent" deep vein thrombosis.威克三(氏)三联征在“无声”深静脉血栓形成中的应用。
J Vasc Surg Venous Lymphat Disord. 2019 Sep;7(5):640-645. doi: 10.1016/j.jvsv.2019.02.011. Epub 2019 May 8.
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Corticosteroids for acute bacterial meningitis.用于急性细菌性脑膜炎的皮质类固醇
Cochrane Database Syst Rev. 2015 Sep 12;2015(9):CD004405. doi: 10.1002/14651858.CD004405.pub5.

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