Kharasch Virginia S, Hui Ning Tat Hamilton, Dumas Helene M, Haley Stephen M, Specht Linda, Colin Andrew A
Pediatric Pulmonary Rehabilitation, Franciscan Hospital for Children, Boston, MA 02135, USA.
Childs Nerv Syst. 2005 Nov;21(11):986-90. doi: 10.1007/s00381-004-1126-9. Epub 2005 May 26.
We reviewed the cases of 11 children <12 years of age with complex medical conditions and respiratory failure requiring chronic positive pressure ventilation (CPPV). We conducted a within-group comparison of average head circumference (HC) percentiles with each child's age-expected 50th percentile value and a between-groups comparison with children with no history of ventilation. We examined the relationship between HC, peak levels of positive inspiratory pressure (PIP), and length of time on CPPV.
We found that children on CPPV had an average HC value at the 71st percentile, significantly greater (p=0.009) than the age-expected 50th percentile; that children on CPPV had a greater (p=0.003) average HC percentile compared with children with complex medical conditions not on CPPV; and that peak levels of PIP had a moderately strong correlation to HC (r=0.689, p=0.019).
We conclude that children on CPPV have larger than expected HC and HC appears related to the peak level of PIP. Research to further investigate the relationship between HC and CPPV in children appears to be warranted.
我们回顾了11名12岁以下患有复杂病症且因呼吸衰竭需要长期正压通气（CPPV）的儿童病例。我们对每个儿童的平均头围（HC）百分位数与按年龄预期的第50百分位数进行了组内比较，并与无通气史的儿童进行了组间比较。我们研究了HC、吸气峰压（PIP）峰值水平和CPPV使用时间之间的关系。
我们发现接受CPPV治疗的儿童平均HC值处于第71百分位数，显著高于（p=0.009）按年龄预期的第50百分位数；与未接受CPPV治疗的患有复杂病症的儿童相比，接受CPPV治疗的儿童平均HC百分位数更高（p=0.003）；并且PIP峰值水平与HC具有中度强相关性（r=0.689，p=0.019）。
我们得出结论，接受CPPV治疗的儿童头围大于预期，且头围似乎与PIP峰值水平有关。进一步研究儿童HC与CPPV之间关系的研究似乎是必要的。
