Cuypers J, Matakas F, Potolicchio S J
J Neurosurg. 1976 Jul;45(1):89-94. doi: 10.3171/jns.1976.45.1.0089.
In cats, brain tissue pressure (BTP) was measured by the wick-catheter method. The BTP was positive, but lower than cerebrospinal fluid pressure. Elevation on central venous pressure led only to a transient proportional increase of BTP. When the calvaria and dura of one hemisphere were removed, the rise of BTP was even less. Water content of the brain was normal in either case, even after prolonged venous hypertension. Venous hypertension led in all cases to a marked increase of the brain volume which was caused by vessel dilatation. In brain edema, produced by rinsing the brain surface with ouabain and concentrated saline, BTP was increased permanently by venous hypertension. The water content of the brain was much greater than normal. From these results it was concluded that congestive edema does not occur in the brain unless the tissue is damaged. However, venous hypertension does cause brain swelling.
在猫身上，采用灯芯导管法测量脑组织压力（BTP）。BTP为正值，但低于脑脊液压力。中心静脉压升高仅导致BTP出现短暂的成比例增加。当去除一侧半球的颅骨和硬脑膜时，BTP的升高甚至更小。在任何一种情况下，即使在长时间静脉高压后，脑含水量均正常。静脉高压在所有情况下均导致脑体积显著增加，这是由血管扩张引起的。在用哇巴因和浓盐水冲洗脑表面所产生的脑水肿中，静脉高压使BTP持续升高。脑含水量远高于正常水平。从这些结果可以得出结论，除非组织受损，否则脑内不会发生充血性水肿。然而，静脉高压确实会导致脑肿胀。
