日本水果和蔬菜摄入量与结直肠癌风险：宫城队列研究

Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study.

作者信息

Sato Yuki, Tsubono Yoshitaka, Nakaya Naoki, Ogawa Keiko, Kurashima Kayoko, Kuriyama Shinichi, Hozawa Atsushi, Nishino Yoshikazu, Shibuya Daisuke, Tsuji Ichiro

机构信息

Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai 980-8575, Japan.

出版信息

Public Health Nutr. 2005 May;8(3):309-14. doi: 10.1079/phn2004681.

DOI:10.1079/phn2004681

PMID:15918928

Abstract

OBJECTIVE

Adequate fruit and vegetable intake has been suggested to protect against colorectal cancer. However, several recent prospective studies have reported no association. We therefore examined the association between fruit and vegetable intakes and the risk of colorectal cancer in a prospective cohort study in Japan.

DESIGN

Between June and August 1990, 47 605 Japanese men and women completed a self-administered questionnaire, including a food-frequency questionnaire. We divided the subjects into quartiles based on their self-reported fruit and vegetable consumption. There were 165 colon cancer and 110 rectal cancer incidences identified during 7 years of follow-up, to the end of December 1997. We used Cox proportional hazards models to estimate the relative risk (RR) of developing colorectal cancer according to the level of fruit and vegetable consumption, applying adjustments for potential confounders.

RESULTS

No statistically significant association was observed between fruit and vegetable consumption and the risk of colorectal cancer. The multivariate RR of colon cancer in the highest quartile of fruit and vegetable intake compared with the lowest was 1.13 (95% confidence interval (CI) 0.73-1.75), the RR for vegetables alone was 1.24 (95% CI 0.79-1.95) and that for fruit alone was 1.45 (95% CI 0.85-2.47). The corresponding multivariate RRs for rectal cancer were 1.12 (95% CI 0.67-1.89), 1.14 (95% CI 0.67-1.93) and 1.41 (95% CI 0.73-2.73).

CONCLUSIONS

We found no association between the consumption of fruit and vegetables and the risk of colorectal cancer among the Japanese population.

摘要

目的

已有研究表明，充足的水果和蔬菜摄入量可预防结直肠癌。然而，最近的几项前瞻性研究报告称二者并无关联。因此，我们在日本的一项前瞻性队列研究中，对水果和蔬菜摄入量与结直肠癌风险之间的关联进行了研究。

设计

1990年6月至8月期间，47605名日本男性和女性完成了一份自填式问卷，其中包括一份食物频率问卷。我们根据受试者自我报告的水果和蔬菜消费量将其分为四分位数。在截至1997年12月底的7年随访期间，共确诊165例结肠癌和110例直肠癌病例。我们使用Cox比例风险模型，根据水果和蔬菜的消费水平估计患结直肠癌的相对风险（RR），并对潜在混杂因素进行了调整。

结果

未观察到水果和蔬菜消费与结直肠癌风险之间存在统计学显著关联。水果和蔬菜摄入量最高四分位数组与最低四分位数组相比，结肠癌的多变量RR为1.13（95%置信区间（CI）0.73 - 1.75），单独蔬菜的RR为1.24（95%CI 0.79 - 1.95），单独水果的RR为1.45（95%CI 0.85 - 2.47）。直肠癌相应的多变量RR分别为1.12（95%CI 0.67 - 1.89）、1.14（95%CI 0.67 - 1.93）和1.41（95%CI 0.73 - 2.73）。