Spahn I, Takács S, Shubin Yu N, Tárkányi F, Coenen H H, Qaim S M
Institut für Nuklearchemie, Forschungszentrum Jülich Gmb H, D-52425 Jülich, Germany.
Appl Radiat Isot. 2005 Aug;63(2):235-9. doi: 10.1016/j.apradiso.2005.03.006.
The radionuclide (169)Yb (T(1/2)=32.0 d) is potentially important for internal radiotherapy. It is generally produced using a nuclear reactor. In this work the possibility of its production at a cyclotron was investigated. A detailed determination of the excitation function of the (169)Tm(p,n)(169)Yb reaction was done over the proton energy range up to 45 MeV using the stacked-foil technique and high-resolution gamma-ray spectrometry. The integral yield of (169)Yb was calculated. Over the optimum energy range E(P)=16-->7 MeV the yield amounts to 1.5 MBq/micro Ah and is thus rather low. A comparison of this production route with the established (168)Yb(n,gamma)(169)Yb reaction at a nuclear reactor is given. The (169)Yb yield via the reactor route is by several orders of magnitude higher than by the cyclotron method. The latter procedure, however, leads to "no-carrier-added" product.
放射性核素（169）镱（半衰期T(1/2)=32.0天）在体内放射治疗中可能具有重要意义。它通常是利用核反应堆生产的。在这项工作中，研究了在回旋加速器上生产该核素的可能性。使用叠层箔技术和高分辨率γ射线能谱法，在高达45 MeV的质子能量范围内，对（169）铥（p，n）（169）镱反应的激发函数进行了详细测定。计算了（169）镱的积分产额。在最佳能量范围E(P)=16→7 MeV内，产额为1.5 MBq/μAh，因此相当低。给出了该生产途径与在核反应堆中已有的（168）镱（n，γ）（169）镱反应的比较。通过反应堆途径产生的（169）镱产额比通过回旋加速器方法高出几个数量级。然而，后一种方法可得到“无载体添加”产物。
