Afolabi B B, Oyeneyin O L, Ogedengbe O K
Department of Obstetrics and Gynecology, Lagos University Teaching Hospital, Lagos, Nigeria.
Int J Gynaecol Obstet. 2005 Jun;89(3):263-7. doi: 10.1016/j.ijgo.2005.02.010. Epub 2005 Apr 2.
To compare the efficacy and safety of 100 microg of intravaginal misoprostol with intracervical Foley catheter for cervical ripening and induction of labor.
One hundred women being induced in the Lagos University Teaching Hospital, Nigeria, were randomized to receive a single 100 microg dose of misoprostol intravaginally or intracervical insertion of Foley catheter. Data analyses were by the Student's t-test and chi-square test.
Misoprostol was more effective in terms of induction to delivery interval (11.84+/-5.43 versus 20.03+/-4.68 h, P<0.05), change in Bishop score, and number delivered within 24 h, in patients with a one-time successful induction. Uterine hyperactivity and rupture were more frequent in the misoprostol group.
A single 100 microg dose of intravaginal misoprostol is more efficacious than intracervical insertion of Foley catheter for cervical ripening and induction of labor. Further studies using lower doses are needed to determine the safest dose.
比较100微克阴道内米索前列醇与宫颈内放置 Foley 导管用于促宫颈成熟和引产的疗效及安全性。
在尼日利亚拉各斯大学教学医院引产的100名妇女被随机分为两组，分别接受单次100微克剂量的阴道内米索前列醇或宫颈内放置 Foley 导管。数据分析采用 Student's t 检验和卡方检验。
对于一次性引产成功的患者，米索前列醇在引产至分娩间隔时间（11.84±5.43 小时对 20.03±4.68 小时，P<0.05）、Bishop 评分变化以及24小时内分娩人数方面更有效。米索前列醇组子宫过度活动和破裂更为常见。
单次100微克剂量的阴道内米索前列醇在促宫颈成熟和引产方面比宫颈内放置 Foley 导管更有效。需要进一步研究使用更低剂量以确定最安全的剂量。
