• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Ethnic and geographical variation in antiphospholipid (Hughes) syndrome.抗磷脂（休斯）综合征的种族和地理差异。
Ann Rheum Dis. 2005 Dec;64(12):1671-6. doi: 10.1136/ard.2005.038448. Epub 2005 May 26.
2
Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation.循环浆细胞有助于产生抗磷脂抗体，与 I 型干扰素上调有关。
J Thromb Haemost. 2019 Jul;17(7):1134-1143. doi: 10.1111/jth.14427. Epub 2019 Mar 30.
3
HLA class II alleles and genetic predisposition to the antiphospholipid syndrome.人类白细胞抗原II类等位基因与抗磷脂综合征的遗传易感性
Autoimmun Rev. 2003 Oct;2(6):387-94. doi: 10.1016/s1568-9972(03)00068-5.
4
New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches.抗磷脂综合征中动脉血栓形成的新生物标志物：基因组学和表观遗传学方法。
Front Immunol. 2019 Apr 16;10:764. doi: 10.3389/fimmu.2019.00764. eCollection 2019.
5
Antiphospholipid syndrome: 30 years and our contribution.抗磷脂综合征：30年历程与我们的贡献。
Int J Rheum Dis. 2015 Feb;18(2):233-41. doi: 10.1111/1756-185X.12438. Epub 2014 Dec 19.
6
Insights into the diagnosis and pathogenesis of the antiphospholipid syndrome.抗磷脂综合征的诊断和发病机制研究进展。
Semin Arthritis Rheum. 2019 Apr;48(5):860-866. doi: 10.1016/j.semarthrit.2018.08.004. Epub 2018 Aug 23.
7
Ethnicity and APS.种族与抗磷脂综合征
J Autoimmun. 2000 Sep;15(2):153-5. doi: 10.1006/jaut.2000.0411.
8
MHC studies of the primary antiphospholipid antibody syndrome and of antiphospholipid antibodies in systemic lupus erythematosus.原发性抗磷脂抗体综合征及系统性红斑狼疮中抗磷脂抗体的主要组织相容性复合体研究
J Rheumatol. 1996 Jul;23(7):1173-9.
9
Genetic aspects of the antiphospholipid syndrome: An update.抗磷脂综合征的遗传学方面：最新进展。
Autoimmun Rev. 2016 May;15(5):433-9. doi: 10.1016/j.autrev.2016.01.005. Epub 2016 Jan 21.
10
The prevalence of antibodies to anionic phospholipids in patients with the primary antiphospholipid syndrome, systemic lupus erythematosus and their relatives and spouses.原发性抗磷脂综合征、系统性红斑狼疮患者及其亲属和配偶中抗阴离子磷脂抗体的患病率。
Rheumatology (Oxford). 2000 Apr;39(4):427-31. doi: 10.1093/rheumatology/39.4.427.

引用本文的文献

1
Genetic factors associated with the co-occurrence of endometriosis with antiphospholipid syndrome (Review).与子宫内膜异位症合并抗磷脂综合征同时出现相关的遗传因素（综述）
Exp Ther Med. 2025 Aug 22;30(4):205. doi: 10.3892/etm.2025.12955. eCollection 2025 Oct.
2
Epidemiology of antiphospholipid syndrome: macro- and microvascular manifestations.抗磷脂综合征的流行病学：大血管和微血管表现。
Rheumatology (Oxford). 2024 Feb 6;63(SI):SI24-SI36. doi: 10.1093/rheumatology/kead571.
3
Positive antiphospholipid antibodies: observation or treatment?抗磷脂抗体阳性：观察还是治疗？
J Thromb Thrombolysis. 2023 Aug;56(2):301-314. doi: 10.1007/s11239-023-02834-6. Epub 2023 Jun 1.
4
Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events.抗磷脂抗体的流行率及其与心血管事件发生的相关性。
JAMA Netw Open. 2023 Apr 3;6(4):e236530. doi: 10.1001/jamanetworkopen.2023.6530.
5
Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study.IgA 抗磷脂抗体的检测不能改善血栓性抗磷脂综合征的分类：一项双中心研究。
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221081129. doi: 10.1177/10760296221081129.
6
Cognitive dysfunction and associated neuroimaging biomarkers in antiphospholipid syndrome: a systematic review.抗磷脂综合征中的认知功能障碍及相关神经影像学生物标志物：系统评价。
Rheumatology (Oxford). 2021 Dec 24;61(1):24-41. doi: 10.1093/rheumatology/keab452.
7
Clinical significance of IgA anti-cardiolipin and IgA anti-β2glycoprotein I antibodies.IgA 抗心磷脂抗体和 IgA 抗β2 糖蛋白 I 抗体的临床意义。
Curr Rheumatol Rep. 2013 Jul;15(7):343. doi: 10.1007/s11926-013-0343-1.
8
Antiphospholipid antibodies in iraqi women with recurrent mid-trimester abortions.伊拉克反复发生孕中期流产妇女的抗磷脂抗体
J Lab Physicians. 2012 Jul;4(2):78-82. doi: 10.4103/0974-2727.105586.
9
Geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults.健康成年人中自身抗体和抗感染抗体的地理差异。
Clin Rev Allergy Immunol. 2012 Apr;42(2):154-63. doi: 10.1007/s12016-010-8241-z.
10
The role of ethnicity, age and gender in venous thromboembolism.种族、年龄和性别在静脉血栓栓塞中的作用。
J Thromb Thrombolysis. 2010 May;29(4):489-96. doi: 10.1007/s11239-009-0365-8.

本文引用的文献

1
Significance of valine/leucine247 polymorphism of beta2-glycoprotein I in antiphospholipid syndrome: increased reactivity of anti-beta2-glycoprotein I autoantibodies to the valine247 beta2-glycoprotein I variant.β2-糖蛋白I缬氨酸/亮氨酸247多态性在抗磷脂综合征中的意义：抗β2-糖蛋白I自身抗体对缬氨酸247β2-糖蛋白I变体的反应性增加。
Arthritis Rheum. 2005 Jan;52(1):212-8. doi: 10.1002/art.20741.
2
Association of HLA-DM polymorphism with the production of antiphospholipid antibodies.HLA - DM基因多态性与抗磷脂抗体产生的关联
Ann Rheum Dis. 2004 Dec;63(12):1645-8. doi: 10.1136/ard.2003.015552.
3
Genetics of antiphospholipid syndrome.抗磷脂综合征的遗传学
Curr Rheumatol Rep. 2004 Dec;6(6):458-62. doi: 10.1007/s11926-004-0025-0.
4
Systemic lupus erythematosus in Tunisia: demographic and clinical analysis of 100 patients.突尼斯的系统性红斑狼疮：100例患者的人口统计学和临床分析
Lupus. 2004;13(3):204-11. doi: 10.1191/0961203303lu530xx.
5
Is HLA class II susceptibility to primary antiphospholipid syndrome different from susceptibility to secondary antiphospholipid syndrome?人类白细胞抗原II类分子对原发性抗磷脂综合征的易感性与对继发性抗磷脂综合征的易感性是否不同？
Lupus. 2004;13(2):125-31. doi: 10.1191/0961203304lu520oa.
6
HLA class II alleles and genetic predisposition to the antiphospholipid syndrome.人类白细胞抗原II类等位基因与抗磷脂综合征的遗传易感性
Autoimmun Rev. 2003 Oct;2(6):387-94. doi: 10.1016/s1568-9972(03)00068-5.
7
HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus.一大组欧洲系统性红斑狼疮患者中抗心磷脂抗体和抗β2糖蛋白I抗体与HLA - DPB1等位基因的关联
Lupus. 2003;12(7):560-3. doi: 10.1191/0961203303lu402oa.
8
High prevalence of prothrombin G20210A mutation among patients with deep venous thrombosis in Lebanon.黎巴嫩深静脉血栓形成患者中凝血酶原G20210A突变的高流行率。
Thromb Haemost. 2003 May;89(5):945-6.
9
Lack of association of beta2-glycoprotein I polymorphisms Val247Leu and Trp316Ser with antiphospholipid antibodies in patients with thrombosis and pregnancy complications.
Br J Haematol. 2003 Mar;120(6):1066-72. doi: 10.1046/j.1365-2141.2003.04187.x.
10
Valine/valine genotype at position 247 of the beta2-glycoprotein I gene in Mexican patients with primary antiphospholipid syndrome: association with anti-beta2-glycoprotein I antibodies.墨西哥原发性抗磷脂综合征患者β2-糖蛋白I基因第247位缬氨酸/缬氨酸基因型：与抗β2-糖蛋白I抗体的关联
Arthritis Rheum. 2003 Feb;48(2):471-4. doi: 10.1002/art.10771.

抗磷脂（休斯）综合征的种族和地理差异。

Ethnic and geographical variation in antiphospholipid (Hughes) syndrome.

作者信息

Uthman I, Khamashta M

机构信息

American University of Beirut, Medical Centre, PO Box 113-6044, Beirut, Lebanon.

出版信息

Ann Rheum Dis. 2005 Dec;64(12):1671-6. doi: 10.1136/ard.2005.038448. Epub 2005 May 26.

DOI:10.1136/ard.2005.038448
PMID:15919676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1755326/
Abstract

Investigation of the clinical epidemiology of the antiphospholipid syndrome (APS) is in its early stages. During the past 20 years, studies of antiphospholipid antibodies (aPL) and APS have been made in many countries and ethno-geographical groups. aPL appear to occur in all populations studied, with some variations noted in their frequency and in the clinical complications. Environmental and genetic factors contribute to ethnic variation and susceptibility to APS and thus inter-ethnic differences in disease patterns may be due to environmental or genetic factors, or both.

摘要

抗磷脂综合征（APS）的临床流行病学研究尚处于早期阶段。在过去20年里，许多国家和不同种族地理群体都开展了抗磷脂抗体（aPL）和APS的研究。在所有研究的人群中似乎都存在aPL，但其频率和临床并发症存在一些差异。环境和遗传因素导致了种族差异以及对APS的易感性，因此疾病模式的种族间差异可能是由环境因素或遗传因素，或两者共同作用所致。