安卡拉痘苗病毒变异株可保护猕猴免受猴痘病毒的呼吸道攻击。
Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus.
作者信息
Stittelaar Koert J, van Amerongen Geert, Kondova Ivanela, Kuiken Thijs, van Lavieren Rob F, Pistoor Frank H M, Niesters Hubert G M, van Doornum Gerard, van der Zeijst Ben A M, Mateo Luis, Chaplin Paul J, Osterhaus Albert D M E
机构信息
Department of Virology, Erasmus MC, Building Hoboken, Room Ee 17.26, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
出版信息
J Virol. 2005 Jun;79(12):7845-51. doi: 10.1128/JVI.79.12.7845-7851.2005.
Abstract
The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naive and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical VV-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox.
摘要
基于痘苗病毒（VV）的传统天花疫苗在初次接种者和免疫个体中均会引发严重并发症。安卡拉改良痘苗病毒（MVA）是一种高度减毒的、复制缺陷型痘苗病毒株，已被证明在人类和免疫功能低下的动物中是安全的，目前正在研究其对天花的疗效。在此，我们在食蟹猴猴痘模型中直接比较了单独使用MVA以及将其与传统的基于VV的疫苗联合使用的效果。基于MVA的天花疫苗可保护猕猴免受猴痘病毒的致命性呼吸道攻击，因此是保护人类免受天花侵害的重要候选疫苗。
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