Engel Gregory, Rockson Stanley G
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Center, Stanford, CA 94305, USA.
Vasc Med. 2005 Feb;10(1):29-32. doi: 10.1191/1358863x05vm579cr.
We report a case of severe digital ulcerations associated with systemic sclerosis, successfully treated with treprostinil (Remodulin). There was improvement within days of the treatment initiation; complete healing was accomplished after 16 weeks of therapy. Patients with systemic sclerosis and peripheral small vessel disease have limited therapeutic options. Treprostinil is a prostacyclin analogue that can be delivered by subcutaneous infusion and is approved in the USA only for treatment of primary pulmonary hypertension. This report provides an impressive example of an alternative, complementary indication for the use of treprostinil.
我们报告一例与系统性硬化症相关的严重指端溃疡，经曲前列尼尔（瑞莫杜林）成功治疗。治疗开始数天内即有改善；治疗16周后完全愈合。患有系统性硬化症和外周小血管疾病的患者治疗选择有限。曲前列尼尔是一种前列环素类似物，可通过皮下输注给药，在美国仅被批准用于治疗原发性肺动脉高压。本报告提供了一个令人印象深刻的关于曲前列尼尔使用的替代、补充适应症的例子。
