硫唑嘌呤治疗后发生的继发性骨髓增生异常综合征与7号染色体畸变有关。
Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7.
作者信息
Knipp Sabine, Hildebrandt Barbara, Richter Jutta, Haas Rainer, Germing Ulrich, Gattermann Norbert
出版信息
Haematologica. 2005 May;90(5):691-3.
PMID:15921387
Abstract
We report 14 cases of secondary myelodysplastic syndromes (sMDS) following treatment with azathioprine for non-malignant disorders. Long-term treatment with azathioprine seems to be associated with an increased risk of MDS and subsequent leukemic transformation.
摘要
我们报告了14例在使用硫唑嘌呤治疗非恶性疾病后发生的继发性骨髓增生异常综合征（sMDS）。长期使用硫唑嘌呤似乎与骨髓增生异常综合征及随后的白血病转化风险增加有关。
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