Renneboog B, Hansen V, Heimann P, De Mulder A, Jannsen F, Ferster A
Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belguim.
Br J Haematol. 1996 Mar;92(3):696-8. doi: 10.1046/j.1365-2141.1996.00400.x.
We describe a case of spontaneously reversible refractory anaemia, a subtype of myelodysplastic syndrome (MDS), with monosomy 7 secondary to chronic treatment with azathioprine (AZA) in a young renal transplant recipient. AZA was stopped after that conventional cytogenetics and fluorescence in situ hybridization (FISH) had demonstrated the existence of a monosomy 7 clone, 4 months later, haematological values had considerably improved and the karyotypic examination as well as the FISH analysis were normal. The spontaneous remission of this MDS with monosomy 7, which is usually associated with a particularly poor prognosis, could be due to the recovery of a better immunosurveillance following the withdrawal of AZA.
我们描述了一例自发可逆性难治性贫血，这是骨髓增生异常综合征（MDS）的一种亚型，在一名年轻的肾移植受者中，因长期使用硫唑嘌呤（AZA）治疗继发7号染色体单体。在传统细胞遗传学和荧光原位杂交（FISH）证实存在7号染色体单体克隆后，停用了AZA。4个月后，血液学指标显著改善，核型检查以及FISH分析均正常。这种通常预后特别差的伴有7号染色体单体的MDS自发缓解，可能是由于停用AZA后免疫监视功能恢复所致。
