Simpson Kerry E, Devine B Craig, Gunn-Moore Danièlle
Division of Veterinary Clinical Studies, University of Edinburgh, Easter Bush, Nr Roslin, Midlothian EH25 9RG, Scotland, UK.
J Feline Med Surg. 2005 Jun;7(3):203-8. doi: 10.1016/j.jfms.2004.08.004.
Clinical toxoplasmosis is commonly reported in the cat, with the most consistent findings being ocular, pulmonic, hepatic, neurological, gastrointestinal and muscular abnormalities. Myocarditis, whilst frequently identified at post-mortem examination, has not been identified ante-mortem. In immunocompromised humans, myocarditis associated with toxoplasmosis is not an uncommon complication. In such cases, lymphocytic myocardial infiltration can lead to depressed myocardial function, which can be associated with congestive heart failure, rhythm disturbances and pericardial effusions. In addition, myocardial failure has been reported in immunocompetent humans associated with active toxoplasmosis [Chandenier J, Jarry G, Nassif D, Douadi Y, Paris L, Thulliez P, Bourges-Petit E, Raccurt C (2000) Congestive heart failure and myocarditis after seroconversion for toxoplasmosis in two immunocompetent patients. European Journal of Clinical Microbiological Infectious Disease 19, 375-379]. Here we describe a cat with echocardiographic changes consistent with infiltrative or inflammatory disease, and elevated IgG and IgM titres to Toxoplasma gondii. There was resolution of these myocardial changes once the toxoplasmosis was treated.
临床型弓形虫病在猫中常有报道，最常见的表现是眼部、肺部、肝脏、神经、胃肠道和肌肉异常。心肌炎虽常在尸检时发现，但生前尚未被确诊。在免疫功能低下的人类中，弓形虫病相关的心肌炎并非罕见的并发症。在这类病例中，淋巴细胞性心肌浸润可导致心肌功能受损，这可能与充血性心力衰竭、心律失常和心包积液有关。此外，在免疫功能正常的人类中，也有与活动性弓形虫病相关的心肌衰竭的报道[Chandenier J, Jarry G, Nassif D, Douadi Y, Paris L, Thulliez P, Bourges-Petit E, Raccurt C（2000年）两名免疫功能正常患者弓形虫病血清转化后出现充血性心力衰竭和心肌炎。《欧洲临床微生物学与传染病杂志》19卷，375 - 379页]。在此，我们描述一只猫，其超声心动图改变与浸润性或炎症性疾病相符，且弓形虫IgG和IgM抗体滴度升高。弓形虫病经治疗后，这些心肌改变得以缓解。
