N-乙基马来酰亚胺在大鼠胃中的辣椒素样活性。
Capsaicin-like activity of N-ethylmaleimide in rat stomach.
作者信息
Evangelista S, Renzi D, Guzzi P, Surrenti C, Santicioli P, Maggi C A
机构信息
Pharmacology Department, Malesii Pharmaceuticals, Firenze, Italy.
出版信息
Gen Pharmacol. 1992 Jan;23(1):39-41. doi: 10.1016/0306-3623(92)90044-k.
PMID:1592225
Abstract
- N-Ethylmaleimide (NEM) and capsaicin induced a release of calcitonin gene-related peptide-like immunoreactivity (CGRP-li) in superfusates from rat gastric corpus. 2. The prior application of capsaicin completely blocked CGRP-li release by NEM while the exposure to NEM reduced the capsaicin-evoked CGRP-li outflow by about 51%. 3. These findings provide evidence that NEM might exert capsaicin-like activity in rat stomach and the release of CGRP-li from capsaicin-sensitive afferent fibres might influence the properties exerted by NEM in this tissue.
摘要
- N-乙基马来酰亚胺（NEM）和辣椒素可诱导大鼠胃体灌流液中降钙素基因相关肽样免疫反应性物质（CGRP-li）的释放。2. 预先应用辣椒素可完全阻断NEM诱导的CGRP-li释放，而暴露于NEM可使辣椒素诱发的CGRP-li流出减少约51%。3. 这些发现表明，NEM可能在大鼠胃中发挥类似辣椒素的活性，辣椒素敏感传入纤维释放的CGRP-li可能影响NEM在该组织中的作用特性。
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