Salinas-Alamán Angel, García-Layana Alfredo, Maldonado Miguel J, Sainz-Gómez Carmen, Alvárez-Vidal Aurora
Department of Ophthalmology, University Clinic, University of Navarra, Pamplona, Spain.
Am J Ophthalmol. 2005 Jul;140(1):23-8. doi: 10.1016/j.ajo.2005.01.044.
To evaluate the role of optical coherence tomography (OCT) in determining choroidal neovascularization (CNV) activity before and after photodynamic therapy (PDT) in patients with age-related macular degeneration (ARMD).
Prospective observational case series.
Institutional study. patient population: Fifty-three patients (62 eyes) with ARMD.
Prospective observational case study.
Presence or absence of leakage on fluorescein angiography, presence of intraretinal or sub-retinal fluid on OCT, and macular and choroidal neovascular complex thickness on OCT.
The macular thickness decreased significantly after PDT (P = .001). However, no significant changes in CNV thickness were measured after PDT (P = .567). Once the diagnosis of ARMD was established before treatment, OCT had a sensitivity of 96.77% for detecting CNV activity. After treatment, OCT had a good sensitivity (95.65%) and a moderate specificity (59.01%) in determining CNV activity, which resulted in a diagnostic efficiency (proportion of correct results) of 82.95%.
OCT appears to be useful for indicating CNV activity. Therefore, it may serve as a complementary technique for deciding the need for PDT and re-treatment in patients with ARMD.
评估光学相干断层扫描（OCT）在确定年龄相关性黄斑变性（ARMD）患者光动力疗法（PDT）前后脉络膜新生血管（CNV）活性中的作用。
前瞻性观察病例系列。
机构研究。患者人群：53例（62只眼）ARMD患者。
前瞻性观察病例研究。
荧光素血管造影上有无渗漏、OCT上有无视网膜内或视网膜下液以及OCT上黄斑和脉络膜新生血管复合体厚度。
PDT后黄斑厚度显著降低（P = 0.001）。然而，PDT后未测得CNV厚度有显著变化（P = 0.567）。在治疗前确诊ARMD后，OCT检测CNV活性的灵敏度为96.77%。治疗后，OCT在确定CNV活性方面具有良好的灵敏度（95.65%）和中等的特异性（59.01%），诊断效率（正确结果比例）为82.95%。
OCT似乎有助于指示CNV活性。因此，它可作为一种辅助技术，用于决定ARMD患者是否需要PDT及再次治疗。
