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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Lee H C, Hardman J M, Lum B K

Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.

Gen Pharmacol. 1992 Jan;23(1):71-4. doi: 10.1016/0306-3623(92)90050-t.

The calcium channel blocker, nicardipine, produced a dose-dependent reduction in the mortality caused by endotoxin in rats. 2. The drug also reduced most of the hematological and gross pathological manifestations of disseminated intravascular coagulation (DIC) caused by endotoxin. 3. The endotoxin-induced monocytopenia but not the granulocytopenia, lymphocytopenia or thrombocytopenia was inhibited by the drug. 4. The results suggest that the protective action of nicardipine is causally related to prevention of the endotoxin-induced DIC and that an effect of the drug on monocytes may be of importance.

钙通道阻滞剂尼卡地平可使大鼠内毒素所致死亡率呈剂量依赖性降低。2. 该药还减轻了内毒素所致弥散性血管内凝血（DIC）的大部分血液学和大体病理学表现。3. 该药可抑制内毒素诱导的单核细胞减少，但对粒细胞减少、淋巴细胞减少或血小板减少无抑制作用。4. 结果提示，尼卡地平的保护作用与预防内毒素诱导的DIC有因果关系，且该药对单核细胞的作用可能很重要。

Lee H C, Hardman J M, Lum B K

Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.

Gen Pharmacol. 1992 Jan;23(1):71-4. doi: 10.1016/0306-3623(92)90050-t.

The calcium channel blocker, nicardipine, produced a dose-dependent reduction in the mortality caused by endotoxin in rats. 2. The drug also reduced most of the hematological and gross pathological manifestations of disseminated intravascular coagulation (DIC) caused by endotoxin. 3. The endotoxin-induced monocytopenia but not the granulocytopenia, lymphocytopenia or thrombocytopenia was inhibited by the drug. 4. The results suggest that the protective action of nicardipine is causally related to prevention of the endotoxin-induced DIC and that an effect of the drug on monocytes may be of importance.

钙通道阻滞剂尼卡地平可使大鼠内毒素所致死亡率呈剂量依赖性降低。2. 该药还减轻了内毒素所致弥散性血管内凝血（DIC）的大部分血液学和大体病理学表现。3. 该药可抑制内毒素诱导的单核细胞减少，但对粒细胞减少、淋巴细胞减少或血小板减少无抑制作用。4. 结果提示，尼卡地平的保护作用与预防内毒素诱导的DIC有因果关系，且该药对单核细胞的作用可能很重要。