Wong T S, Kwong D L-W, Sham J, Wei W I, Kwong Y L, Yuen A P-W
Department of Surgery, The University of Hong Kong, Hong Kong, China.
Eur J Surg Oncol. 2005 Jun;31(5):555-8. doi: 10.1016/j.ejso.2005.01.005.
We evaluated the clinicopathologic relevance of plasma osteopontin (OPN) level in nasopharyngeal carcinoma patients.
Seventy-two plasma samples were collected from patients with undifferentiated nasopharyngeal carcinoma (NPC) before radiotherapy. Plasma OPN level was determined by quantitative sandwich enzyme immunoassay. The plasma OPN level was evaluated for its clinicopathologic relevance.
The mean plasma OPN level was significantly higher in NPC patients than in normal controls (184.66 vs 75.89 ng/ml, p<0.001). In addition, high OPN level was found in the patients with advanced cancer and was correlated with neck node metastasis (p<0.05).
Our findings indicated a potential role of OPN in the pathogenesis and nodal metastasis of undifferentiated NPC.
我们评估了鼻咽癌患者血浆骨桥蛋白（OPN）水平的临床病理相关性。
收集72例未分化鼻咽癌（NPC）患者放疗前的血浆样本。采用定量夹心酶免疫测定法测定血浆OPN水平。评估血浆OPN水平的临床病理相关性。
NPC患者的血浆OPN平均水平显著高于正常对照组（184.66对75.89 ng/ml，p<0.001）。此外，晚期癌症患者的OPN水平较高，且与颈部淋巴结转移相关（p<0.05）。
我们的研究结果表明OPN在未分化NPC的发病机制和淋巴结转移中具有潜在作用。
