头颈部癌症患者骨桥蛋白水平升高的临床意义
Clinical significance of elevated osteopontin levels in head and neck cancer patients.
作者信息
Eto Mayumi, Kodama Satoru, Nomi Nozomi, Uemura Naoki, Suzuki Masashi
机构信息
Department of Otolaryngology, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hazama-machi, Yufu, Oita 879-5593, Japan.
出版信息
Auris Nasus Larynx. 2007 Sep;34(3):343-6. doi: 10.1016/j.anl.2006.11.012. Epub 2007 Jan 24.
OBJECTIVES
Osteopontin (OPN) is associated with several human malignancies, but the role of OPN in head and neck cancer (HNC) remains unclear. We investigated the clinicopathologic relevance of serum OPN levels in HNC patients.
METHODS
Serum OPN levels in HNC patients were determined by quantitative sandwich enzyme immunoassay (EIA). OPN levels and their correlation with clinical features were examined. In addition, serum squamous cell carcinoma (SCC) antigen was examined simultaneously.
RESULTS
The mean OPN level was significantly higher in HNC patients (99.5 ng/ml) than in control subjects (55.3 ng/ml). OPN levels were significantly higher in patients with advanced stage HNC than in patients with early stage HNC. OPN levels did not correlate with SCC antigen levels.
CONCLUSIONS
OPN may play a role in the pathogenesis of head and neck cancer (HNC), and serum OPN may be a potential biomarker of HNC.
目的
骨桥蛋白（OPN）与多种人类恶性肿瘤相关，但OPN在头颈癌（HNC）中的作用仍不清楚。我们研究了HNC患者血清OPN水平与临床病理的相关性。
方法
采用定量夹心酶免疫测定法（EIA）测定HNC患者血清OPN水平。检测OPN水平及其与临床特征的相关性。此外，同时检测血清鳞状细胞癌（SCC）抗原。
结果
HNC患者的平均OPN水平（99.5 ng/ml）显著高于对照组（55.3 ng/ml）。晚期HNC患者的OPN水平显著高于早期HNC患者。OPN水平与SCC抗原水平无关。
结论
OPN可能在头颈癌（HNC）的发病机制中起作用，血清OPN可能是HNC的潜在生物标志物。
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