Haeryfar S M Mansour
Cellular Biology & Viral Immunology Sections, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Immunol. 2005 Jun;26(6):311-7. doi: 10.1016/j.it.2005.04.002.
Plasmacytoid pre-dendritic cells (pDCs) comprise a pivotal element of antiviral immune responses. They recognize viral components, leading to type I interferon (IFN) production, and affect adaptive defense strategies designed to eliminate viral pathogens. These strategies include the ability of pDCs to modulate virus-specific CD8(+) T-cell responses. Although a great deal has been learned recently about pDCs, our knowledge of whether, how and why pDCs might function as antigen-presenting cells is extremely limited, and now is a prime time for exploring the unknowns of this area. This Opinion will focus on the IFN production and T-cell priming capacity of pDCs, and will argue that IFN production (and not T-cell priming) is the main function of pDCs during viral infection.
浆细胞样前体树突状细胞（pDC）是抗病毒免疫反应的关键组成部分。它们识别病毒成分，导致I型干扰素（IFN）产生，并影响旨在消除病毒病原体的适应性防御策略。这些策略包括pDC调节病毒特异性CD8(+) T细胞反应的能力。尽管最近我们对pDC有了很多了解，但我们对pDC是否、如何以及为何可能作为抗原呈递细胞发挥作用的认识极其有限，现在正是探索该领域未知之处的黄金时期。本观点将聚焦于pDC的IFN产生和T细胞启动能力，并认为IFN产生（而非T细胞启动）是病毒感染期间pDC的主要功能。
