Department of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E OT5, Canada.
Surgery, Faculty of Health Sciences, McMaster University, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada.
Int J Mol Sci. 2021 Jan 23;22(3):1118. doi: 10.3390/ijms22031118.
Dendritic cells (DC) connect the innate and adaptive arms of the immune system and carry out numerous roles that are significant in the context of viral disease. Their functions include the control of inflammatory responses, the promotion of tolerance, cross-presentation, immune cell recruitment and the production of antiviral cytokines. Based primarily on the available literature that characterizes the behaviour of many DC subsets during Severe acute respiratory syndrome (SARS) and coronavirus disease 2019 (COVID-19), we speculated possible mechanisms through which DC could contribute to COVID-19 immune responses, such as dissemination of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to lymph nodes, mounting dysfunctional inteferon responses and T cell immunity in patients. We highlighted gaps of knowledge in our understanding of DC in COVID-19 pathogenesis and discussed current pre-clinical development of therapies for COVID-19.
树突状细胞 (DC) 连接着先天免疫和适应性免疫系统的两支，在病毒疾病的背景下发挥着许多重要的作用。它们的功能包括控制炎症反应、促进耐受、交叉呈递、免疫细胞募集和产生抗病毒细胞因子。主要基于描述严重急性呼吸综合征 (SARS) 和 2019 冠状病毒病 (COVID-19) 期间许多 DC 亚群行为的现有文献，我们推测了 DC 可能有助于 COVID-19 免疫反应的可能机制，例如将严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 传播到淋巴结，在患者中引发功能失调的干扰素反应和 T 细胞免疫。我们强调了我们对 COVID-19 发病机制中 DC 的理解存在知识空白，并讨论了 COVID-19 治疗的当前临床前开发。
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