Soumelis V, Liu Y-J
Inserm U653 and Department of Immunology, Institut Curie, Paris, France.
Eur J Immunol. 2006 Sep;36(9):2286-92. doi: 10.1002/eji.200636026.
Plasmacytoid dendritic cell precursors (pDC/IPC) are the major producers of type I interferon and have the unique ability to link innate and adaptive immunity. After producing large amounts of type I IFN in response to microbial stimulation, they can differentiate into DC capable of stimulating naive T cells and modulate the adaptive immune response. In this review, we focus on the transition between these two highly specialized cell types, which is accompanied by major morphological, structural and functional changes, many of which remain to be fully characterized. We propose that the plasmacytoid and dendritic morphologies correspond to distinct differentiation states and effector functions.
浆细胞样树突状细胞前体（pDC/IPC）是I型干扰素的主要产生者，具有连接天然免疫和适应性免疫的独特能力。在响应微生物刺激产生大量I型干扰素后，它们可分化为能够刺激初始T细胞的树突状细胞，并调节适应性免疫反应。在本综述中，我们聚焦于这两种高度特化细胞类型之间的转变，这一转变伴随着主要的形态、结构和功能变化，其中许多变化仍有待充分表征。我们提出，浆细胞样和树突状形态分别对应着不同的分化状态和效应功能。
