线粒体DNA非母系遗传的更多证据？
More evidence for non-maternal inheritance of mitochondrial DNA?
作者信息
Bandelt H-J, Kong Q-P, Parson W, Salas A
出版信息
J Med Genet. 2005 Dec;42(12):957-60. doi: 10.1136/jmg.2005.033589. Epub 2005 May 27.
BACKGROUND
A single case of paternal co-transmission of mitochondrial DNA (mtDNA) in humans has been reported so far.
OBJECTIVE
To find potential instances of non-maternal inheritance of mtDNA.
METHODS
Published medical case studies (of single patients) were searched for irregular mtDNA patterns by comparing the given haplotype information for different clones or tissues with the worldwide mtDNA database as known to date-a method that has proved robust and reliable for the detection of flawed mtDNA sequence data.
RESULTS
More than 20 studies were found reporting clear cut instances with mtDNAs of different ancestries in single individuals. As examples, cases are reviewed from recent published reports which, at face value, may be taken as evidence for paternal inheritance of mtDNA or recombination.
CONCLUSIONS
Multiple types (or recombinant types) of quite dissimilar mitochondrial DNA from different parts of the known mtDNA phylogeny are often reported in single individuals. From re-analyses and corrigenda of forensic mtDNA data, it is apparent that the phenomenon of mixed or mosaic mtDNA can be ascribed solely to contamination and sample mix up.
背景
迄今为止，人类中仅报道过一例线粒体DNA（mtDNA）的父系共传递情况。
目的
寻找mtDNA非母系遗传的潜在实例。
方法
通过将不同克隆或组织的给定单倍型信息与目前已知的全球mtDNA数据库进行比较，在已发表的（针对单个患者的）医学病例研究中搜索不规则的mtDNA模式——这种方法已被证明在检测有缺陷的mtDNA序列数据方面稳健可靠。
结果
发现20多项研究报告了单个个体中存在不同谱系mtDNA的明确实例。作为示例，对近期发表报告中的病例进行了回顾，这些病例表面上可能被视为mtDNA父系遗传或重组的证据。
结论
在单个个体中经常报告来自已知mtDNA系统发育不同部分的多种类型（或重组类型）的截然不同的线粒体DNA。从法医mtDNA数据的重新分析和勘误中可以明显看出，混合或镶嵌mtDNA现象完全可归因于污染和样本混淆。
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