载脂蛋白E4可能是导致帕金森病19号染色体连锁峰值的原因。
Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease.
作者信息
Martinez Maria, Brice Alexis, Vaughan Jenny R, Zimprich Alexander, Breteler Monique M B, Meco Giuseppe, Filla Alessandro, Farrer Matthew J, Bétard Christine, Singleton Andrew, Hardy John, De Michele Giuseppe, Bonifati Vincenzo, Oostra Ben A, Gasser Thomas, Wood Nick W, Dürr Alexandra
机构信息
INSERM EMI00-06, Evry, France.
出版信息
Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):72-4. doi: 10.1002/ajmg.b.30196.
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
对患有帕金森病的同胞对的载脂蛋白E基因型分析表明，E4等位基因在共享19号染色体相邻标记的个体中过度存在。这表明载脂蛋白E4是该区域连锁峰的原因，并且它是帕金森病的一个适度风险因素。
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