一种来自多刺瓦尔瑟木的不寻常喹啉酮生物碱。

An unusual quinolinone alkaloid from Waltheria douradinha.

作者信息

Hoelzel Solange C S M, Vieira Eleno R, Giacomelli Sandro R, Dalcol Ionara I, Zanatta Nilo, Morel Ademir F

机构信息

Departamento de Química (NPPN), Universidade Federal de Santa Maria, CEP: 97105-900 Santa Maria, RS, Brazil.

出版信息

Phytochemistry. 2005 May;66(10):1163-7. doi: 10.1016/j.phytochem.2005.03.019.

DOI:10.1016/j.phytochem.2005.03.019

PMID:15924921

Abstract

The chemical investigation of the methanolic extract of the root bark of Waltheria douradinha (Sterculiaceae) afforded an unusual quinolinone alkaloid named waltherione-A (1). Its structure was determined mainly by NMR spectroscopic methods. The antibacterial activity of waltherione-A (1) and the corresponding O-methylated derivative (2) was tested against three gram-negative and three gram-positive bacteria, with only (2) having moderate activity.

摘要

对多花蛇婆子（梧桐科）根皮甲醇提取物进行化学研究，得到了一种名为waltherione-A（1）的不寻常喹啉酮生物碱。其结构主要通过核磁共振光谱法确定。测试了waltherione-A（1）和相应的O-甲基化衍生物（2）对三种革兰氏阴性菌和三种革兰氏阳性菌的抗菌活性，只有（2）具有中等活性。