Gressler Vanessa, Stüker Caroline Z, Dias Gilvan de O C, Dalcol Ionara I, Burrow Robert A, Schmidt Juergen, Wessjohann Ludger, Morel Ademir F
Departamento de Química (NPPN), Universidade Federal de Santa Maria, Santa Maria RS, Brazil.
Phytochemistry. 2008 Feb;69(4):994-9. doi: 10.1016/j.phytochem.2007.10.018.
A phytochemical investigation of the stems of Waltheria douradinha resulted in isolation of two 4-quinolone alkaloids, waltherione B and vanessine, along with three known alkaloids, waltherione A, antidesmone and O-methyltembamide. Their structures were elucidated on the basis of their 2D NMR spectroscopic analyses, and from X-ray crystallographic analysis of waltherione A and the O-methyl derivative of waltherione B. Additionally, waltherione B and vanessine, and the O- and N-methyl derivatives of waltherione A and waltherione B, were evaluated for their antimicrobial activities; only vanessine displayed any (weak) antimicrobial activity.
对硬毛地桃花茎进行植物化学研究，分离得到两种4-喹诺酮生物碱，即硬毛地桃花碱B和瓦内斯碱，以及三种已知生物碱，硬毛地桃花碱A、安替司莫宁和O-甲基坦巴胺。根据二维核磁共振光谱分析以及硬毛地桃花碱A和硬毛地桃花碱B的O-甲基衍生物的X射线晶体学分析确定了它们的结构。此外，还评估了硬毛地桃花碱B和瓦内斯碱以及硬毛地桃花碱A和硬毛地桃花碱B的O-和N-甲基衍生物的抗菌活性；只有瓦内斯碱表现出任何（微弱的）抗菌活性。
