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钟花树茎皮中的一种脑苷脂——spathoside及其他抗菌成分。

Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata.

作者信息

Mbosso Emmanuel Jean Teinkela, Ngouela Silvère, Nguedia Jules Clément Assob, Penlap Véronique, Rohmer Michel, Tsamo Etienne

机构信息

Faculté des Sciences, Laboratoire de Substances Naturelles et Synthèse Organique, Département de Chimie Organique, Université de Yaoundé I, BP 812 Yaoundé, Cameroun.

出版信息

Nat Prod Res. 2008 Mar 10;22(4):296-304. doi: 10.1080/14786410701766281.

Abstract

Spathoside, a new cerebroside was isolated from the stem bark of Spathodea campanulata, besides known compounds (n-alkanes, linear aliphatic alcohols, sitosterol and their esters, beta-sitosterol-3-O-beta-D-glucopyranoside, oleanolic acid, pomolic acid, p-hydroxybenzoic acid and phenylethanol esters). The structures of the isolated compounds were established by spectroscopic studies. The antibacterial activity of the isolated compounds against a wide range of microorganisms was examined. They inhibited significantly the growth of some gram-positive and -negative bacteria.

摘要

从苞萼木的茎皮中分离出一种新的脑苷脂——spathoside,此外还分离出了一些已知化合物(正构烷烃、直链脂肪醇、甾醇及其酯类、β-谷甾醇-3-O-β-D-葡萄糖苷、齐墩果酸、坡模酸、对羟基苯甲酸和苯乙醇酯)。通过光谱研究确定了分离出的化合物的结构。检测了分离出的化合物对多种微生物的抗菌活性。它们显著抑制了一些革兰氏阳性菌和阴性菌的生长。

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