Kamarajan Chella, Porjesz Bernice, Jones Kevin A, Choi Keewhan, Chorlian David B, Padmanabhapillai Ajayan, Rangaswamy Madhavi, Stimus Arthur T, Begleiter Henri
Neurodynamics Laboratory, Department of Psychiatry, SUNY Downstate Medical Center, Box 1203, 450 Clarkson Avenue, Brooklyn, NY 11203, USA.
Biol Psychol. 2005 Jul;69(3):353-73. doi: 10.1016/j.biopsycho.2004.08.004. Epub 2004 Nov 21.
Response inhibition is considered a core dimension in alcoholism and its co-existing disorders. The major objective of this study is to compare the magnitude and spatial distribution of ERP components during response activation and inhibition in alcoholics (N = 30) and normal controls (N = 30) using a visual Go/No-Go task. The results indicate that alcoholics manifest a decreased P3(00) amplitude during Go as well as No-Go conditions. The difference between Go and No-Go processing was more evident in controls than in alcoholics. The topography of current source density in alcoholics during the P3 response was found to be very different from that of normals, suggesting that alcoholics perhaps activated inappropriate brain circuitry during cognitive processing. The significantly reduced No-Go P3 along with the relatively less anteriorized CSD topography during No-Go condition suggests poor inhibitory control in alcoholics. It is proposed that the No-Go P3, the electrophysiological signature of response inhibition, can be considered as an endophenotypic marker in alcoholism.
反应抑制被认为是酒精中毒及其并存障碍的一个核心维度。本研究的主要目的是使用视觉Go/No-Go任务，比较酗酒者（N = 30）和正常对照组（N = 30）在反应激活和抑制过程中ERP成分的幅度和空间分布。结果表明，酗酒者在Go和No-Go条件下均表现出P3(00)波幅降低。Go和No-Go处理之间的差异在对照组中比在酗酒者中更明显。发现酗酒者在P3反应期间电流源密度的地形图与正常人的非常不同，这表明酗酒者在认知处理过程中可能激活了不适当的脑回路。在No-Go条件下，No-Go P3显著降低以及电流源密度地形图相对较少向前移位，表明酗酒者的抑制控制较差。有人提出，No-Go P3作为反应抑制的电生理特征，可以被视为酒精中毒的一种内表型标记。
