Pfefferbaum A, Rosenbloom M, Ford J M
Alcohol. 1987 Jul-Aug;4(4):275-81. doi: 10.1016/0741-8329(87)90023-1.
The P3 component of the event-related potential (ERP) was recorded during a Go/No-Go task from 42 alcoholic subjects, abstinent for 11-63 days, and 66 normal adult volunteers. In two different tasks, ERPs were elicited by visually presented words which provided explicit response instructions to Go (PUSH) or No-Go (WAIT). In the Noise Task, half of both Go and No-Go stimuli were degraded with ampersands (&P&U&S&H&, &W&A&I&T&). In the Probability Task, the probability of the Go stimulus was 25% and No-Go 75% on one run and the proportion reversed on another run. For both tasks, the amplitude of alcoholics' P3 was smaller than that of controls to the Go but not to the No-Go stimulus. There was a similar, but less pronounced trend for P3 latency to be delayed in alcoholic subjects for the Go, but not No-Go stimuli for the Noise Task. The P3 changes in alcoholics are consistent with those seen in several disease states which produce cognitive impairment.
在一项Go/No-Go任务中，记录了42名戒酒11至63天的酒精成瘾者和66名正常成年志愿者的事件相关电位（ERP）的P3成分。在两项不同的任务中，通过视觉呈现的单词诱发ERP，这些单词提供了明确的Go（按下）或No-Go（等待）反应指令。在噪声任务中，Go和No-Go刺激的一半都用符号（&P&U&S&H&，&W&A&I&T&）进行了降解。在概率任务中，一次运行中Go刺激的概率为25%，No-Go刺激的概率为75%，另一次运行中比例相反。对于这两项任务，酒精成瘾者对Go刺激的P3波幅小于对照组，但对No-Go刺激则不然。在噪声任务中，酒精成瘾者对Go刺激的P3潜伏期有类似但不太明显的延迟趋势，而对No-Go刺激则没有。酒精成瘾者的P3变化与在几种导致认知障碍的疾病状态中观察到的变化一致。
