Biswas D, Borkakoty B J, Mahanta J, Jampa L, Deouri L C
Regional Medical Research Centre, North East Region (Indian Council of Medical Research), P.O. Box-105, Dibrugarh - 786001 Assam, India.
J Assoc Physicians India. 2007 Oct;55:701-4.
To study the prevalence of hepatitis B virus (HBV) infection among an isolated tribe of Northeast India that migrated long back from Tibet.
Randomly selected 438 subjects from Idu Mishmi tribe of Arunachal Pradesh were screened for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), hepatitis B surface antibody (anti-HBs), envelope antigen (HBeAg) using ELISA kits.
The point prevalence of HBsAg was found to be 21.2% (93/438). Anti-HBc prevalence was 92.3% (193/209). Anti-HBs above 10 IU/ml were detected in 48% (96/200). Prevalence of HBeAg was higher (42.1%, 16/38) in children (less than 15 years) compared to adolescent and adults (32.7%, 18/55). History of hepatitis was significantly associated with positive HBsAg status (p < 0.000).
Hepatitis B virus infection is hyperendemic among Idu Mishmi tribe of Arunachal Pradesh, India. Though, the route of transmission could not be ascertained, but the high HBV infection (78.6%) among less than 5 yrs and the finding of 58.4% of HBsAg positive mothers bearing HBsAg positive child indicates possibility of vertical transmission in this setting.
研究印度东北部一个从西藏长期迁徙而来的与世隔绝部落中乙型肝炎病毒（HBV）感染的流行情况。
从阿鲁纳恰尔邦的伊杜米什米部落随机选取438名受试者，使用酶联免疫吸附测定（ELISA）试剂盒检测乙肝表面抗原（HBsAg）、乙肝核心抗体（抗-HBc）、乙肝表面抗体（抗-HBs）、包膜抗原（HBeAg）。
HBsAg的点流行率为21.2%（93/438）。抗-HBc流行率为92.3%（193/209）。在200名受试者中，检测到抗-HBs高于10国际单位/毫升的比例为48%（96/200）。与青少年和成年人（32.7%，18/55）相比，儿童（小于15岁）中HBeAg的流行率更高（42.1%，16/38）。肝炎病史与HBsAg阳性状态显著相关（p < 0.000）。
在印度阿鲁纳恰尔邦的伊杜米什米部落中，乙型肝炎病毒感染呈高度地方性流行。虽然传播途径尚无法确定，但5岁以下儿童中高HBV感染率（78.6%）以及58.4%的HBsAg阳性母亲生育HBsAg阳性孩子这一发现表明，在这种情况下存在垂直传播的可能性。
