Urbina Elaine M, Kieltkya Lyn, Tsai Jeffrey, Srinivasan Sathanur R, Berenson Gerald S
Cincinnati Children's Hospital Medical Center and The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA.
Am J Hypertens. 2005 Jun;18(6):767-71. doi: 10.1016/j.amjhyper.2004.12.017.
Cardiovascular (CV) risk factors are associated with abnormalities in vascular function and structure. Arterial distensibility decreases with age and extent of arteriosclerosis. Mediators of arteriosclerosis may affect segments of the vascular tree differently, and information is limited on vascular changes of the brachial artery. Therefore, we explored the effect of multiple CV risk factors on brachial artery distensibility (BrachD).
A cross-sectional study of CV risk factors and BrachD was performed in an ongoing epidemiologic study (the Bogalusa Heart Study). Data were collected on 803 young adults (42% male, 72% white, aged 19 to 37 years) including BrachD measured by pulse waveform analysis (DynaPulse 2000A, Pulse Metric, Inc.) CV risk factors (anthropometric, hemodynamic, and metabolic variables) were considered abnormal if ranked in the highest age-, ethnicity-, and sex-specific quartile for this population (lowest quartile for HDL).
BrachD was significantly lower in African American than in white subjects (6.33% v 6.76% Delta/mm Hg, P < .005). An inverse linear relationship was noted between BrachD and number of CV risk factors clustering in an individual (P < .0001 trend analysis).
In young adults, increasing numbers of adverse CV risk factors is associated with decreased brachial artery distensibility. Noninvasive brachial artery function measures are useful in measuring subclinical arteriosclerotic vascular changes.
心血管（CV）危险因素与血管功能和结构异常相关。动脉扩张性随年龄和动脉硬化程度而降低。动脉硬化的介质可能对血管树的不同节段产生不同影响，而关于肱动脉血管变化的信息有限。因此，我们探讨了多种CV危险因素对肱动脉扩张性（BrachD）的影响。
在一项正在进行的流行病学研究（博加卢萨心脏研究）中，对CV危险因素和BrachD进行了横断面研究。收集了803名年轻人（42%为男性，72%为白人，年龄19至37岁）的数据，包括通过脉搏波形分析（DynaPulse 2000A，Pulse Metric公司）测量的BrachD。如果CV危险因素（人体测量、血液动力学和代谢变量）在此人群的年龄、种族和性别特异性四分位数中排名最高（HDL为最低四分位数），则被视为异常。
非裔美国人的BrachD显著低于白人（6.33%对6.76%Δ/mm Hg，P <.005）。在个体中，BrachD与聚集的CV危险因素数量之间存在负线性关系（P <.0001趋势分析）。
在年轻人中，不良CV危险因素数量的增加与肱动脉扩张性降低相关。无创肱动脉功能测量有助于测量亚临床动脉硬化血管变化。
