Bos J A, Wollmer P, Bakker W, Hannappel E, Lachmann B
Department of Anaesthesiology, Erasmus University, Rotterdam, The Netherlands.
J Appl Physiol (1985). 1992 Apr;72(4):1413-7. doi: 10.1152/jappl.1992.72.4.1413.
We measured clearance of 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) in rabbits with experimentally increased alveolar surfactant content. In one group of animals, surfactant production was increased by treatment with ambroxol, and another group of animals was treated with tracheal instillation of natural surfactant. A group of untreated control animals and animals treated with instillation of saline were also studied. Clearance was measured during standard conditions of mechanical ventilation and during ventilation with large tidal volumes. In ambroxol- and surfactant-treated groups, clearance rate was reduced compared with untreated control animals. In contrast, clearance rate increased after saline instillation. The differences were observed at both modes of ventilation. The findings indicate that the pulmonary surfactant system is a rate-limiting factor for the clearance of 99mTc-DTPA and that the volume dependence of clearance is not explained by stretching of the alveolar wall only.
我们测量了实验性增加肺泡表面活性物质含量的家兔体内99mTc标记的二乙三胺五乙酸（99mTc-DTPA）的清除率。在一组动物中，通过氨溴索治疗增加表面活性物质的产生，另一组动物则通过气管内滴注天然表面活性物质进行治疗。还研究了一组未经治疗的对照动物以及接受盐水滴注治疗的动物。在机械通气的标准条件下以及大潮气量通气期间测量清除率。与未经治疗的对照动物相比，氨溴索和表面活性物质治疗组的清除率降低。相反，盐水滴注后清除率增加。在两种通气模式下均观察到差异。这些发现表明，肺表面活性物质系统是99mTc-DTPA清除的限速因素，并且清除率的容量依赖性不能仅通过肺泡壁的拉伸来解释。
