Nilsson K, Wollmer P
Department of Clinical Physiology, University of Lund, Sweden.
Clin Physiol. 1992 Sep;12(5):587-94. doi: 10.1111/j.1475-097x.1992.tb00361.x.
We measured the pulmonary clearance of inhaled 99mTc-DTPA and 99mTc-albumin in rabbits with surfactant dysfunction induced by dioctyl sodium sulphosuccinate and in rabbits with lung injury induced by oleic acid. The animals were tracheotomized and mechanically ventilated. After inhalation of 99mTc-albumin in ten animals, clearance of the tracer from the lungs was monitored for 90 min. The first 30 min was a control period. Dioctyl sodium sulphosuccinate was then administered in aerosol and after another 30 min oleic acid was injected intravenously. Ten other rabbits were given 99mTc-DTPA, and clearance was externally recorded for 60 min. Five animals inhaled detergent aerosol and five animals were given oleic acid intravenously after 30 min. Airway pressures, tidal volume, and arterial blood gases were measured before and after each intervention. The half-life of 99mTc-albumin in the lung was 442 +/- 123 min during the control period, 363 +/- 52 min after detergent administration, and 134 +/- 18 min after oleic acid administration (P less than 0.05 compared to control and P less than 0.01 compared to the period after detergent). The half-life of 99mTc-DTPA was 94 +/- 16 min before and 10 +/- 0.6 min (P less than 0.01) after detergent administration and 75 +/- 12 min before and 18 +/- 1.8 min (P less than 0.01) after oleic acid administration. Gas exchange was not affected by administration of dioctyl sodium sulphosuccinate but markedly impaired after injection of oleic acid. Compliance of the respiratory system remained unaffected by detergent but decreased after injection of oleic acid.(ABSTRACT TRUNCATED AT 250 WORDS)
我们测定了吸入99m锝-二乙三胺五乙酸（99mTc-DTPA）和99m锝-白蛋白后，由磺基琥珀酸二辛酯钠诱导产生表面活性剂功能障碍的家兔以及由油酸诱导产生肺损伤的家兔的肺清除率。动物行气管切开并进行机械通气。给10只动物吸入99mTc-白蛋白后，监测示踪剂在肺内90分钟的清除情况。前30分钟为对照期。然后以气雾剂形式给予磺基琥珀酸二辛酯钠，再过30分钟后静脉注射油酸。另外10只家兔给予99mTc-DTPA，并对外记录60分钟的清除情况。5只动物吸入去污剂气雾剂，5只动物在30分钟后静脉注射油酸。在每次干预前后测量气道压力、潮气量和动脉血气。对照期肺内99mTc-白蛋白的半衰期为442±123分钟，给予去污剂后为363±52分钟，给予油酸后为134±18分钟（与对照期相比P<0.05，与给予去污剂后的时期相比P<0.01）。99mTc-DTPA的半衰期在给予去污剂前为94±16分钟，给予后为10±0.6分钟（P<0.01）；在给予油酸前为75±12分钟，给予后为18±1.8分钟（P<0.01）。气体交换不受磺基琥珀酸二辛酯钠给药的影响，但在注射油酸后明显受损。呼吸系统的顺应性不受去污剂影响，但在注射油酸后降低。（摘要截短至250字）
