Pilz Stefan, Horejsi Renate, Möller Reinhard, Almer Gunter, Scharnagl Hubert, Stojakovic Tatjana, Dimitrova Roumiana, Weihrauch Gisela, Borkenstein Martin, Maerz Winfried, Schauenstein Konrad, Mangge Harald
Clinical Institute of Medical and Chemical Laboratory Diagnosis, Medical University of Graz, A-8036 Graz, Austria.
J Clin Endocrinol Metab. 2005 Aug;90(8):4792-6. doi: 10.1210/jc.2005-0167. Epub 2005 May 31.
There is growing evidence that adiponectin, the most abundant adipocytokine of adipose tissue cells, plays a crucial role in advanced atherosclerosis.
The objective of the study was to evaluate the role of adiponectin in early atherosclerosis.
One hundred forty obese juveniles (mean age, 13.5 +/- 4.4 yr) and 100 age-matched, healthy, normal-weight controls from the STYrian Juvenile Obesity Study were investigated. We measured adipocytokines, inflammatory biomarkers, parameters of insulin resistance, and lipid subfractions. Intima-media thickness (IMT) of common carotid arteries was determined by ultrasonography. Furthermore, lipometric measurements were performed in obese juveniles to determine the topographic distribution of sc adipose tissue (SAT).
Compared with controls, the group of obese juveniles exhibited a significantly increased IMT (P < 0.001) and elevated high-sensitive C-reactive protein (P < 0.001), indicating early stages of atherosclerosis. Serum levels of adiponectin were highly significantly negatively correlated with carotid IMT, even after controlling for common cardiovascular risk factors (P < 0.001; r = -0.34). Furthermore, adiponectin was positively correlated with high-density lipoprotein-free cholesterol and serum apolipoprotein-A1 and negatively with triglycerides, insulin resistance, uric acid, and serum transaminases. By a multiple regression analysis, adiponectin was shown to be the strongest predictive variable for carotid IMT. Finally, adiponectin was found positively correlated with SAT thickness of the rear and inner thigh in boys and negatively with the SAT thickness of the neck in girls.
In summary, our study describes an influence of SAT topography on adiponectin serum levels and provides first evidence that incipient atherosclerosis is associated with low serum levels of this adipocytokine.
越来越多的证据表明，脂联素作为脂肪组织细胞中含量最丰富的脂肪因子，在晚期动脉粥样硬化中起着关键作用。
本研究旨在评估脂联素在早期动脉粥样硬化中的作用。
对来自施蒂里亚青少年肥胖研究的140名肥胖青少年（平均年龄13.5±4.4岁）和100名年龄匹配、健康、体重正常的对照者进行了调查。我们测量了脂肪因子、炎症生物标志物、胰岛素抵抗参数和脂质亚组分。通过超声检查确定颈总动脉的内膜中层厚度（IMT）。此外，对肥胖青少年进行了脂肪测量，以确定皮下脂肪组织（SAT）的地形分布。
与对照组相比，肥胖青少年组的IMT显著增加（P<0.001），高敏C反应蛋白升高（P<0.001），表明处于动脉粥样硬化的早期阶段。即使在控制了常见的心血管危险因素后，脂联素的血清水平与颈动脉IMT仍呈高度显著负相关（P<0.001；r=-0.34）。此外，脂联素与高密度脂蛋白游离胆固醇和血清载脂蛋白A1呈正相关，与甘油三酯、胰岛素抵抗、尿酸和血清转氨酶呈负相关。通过多元回归分析，脂联素被证明是颈动脉IMT的最强预测变量。最后，发现脂联素与男孩后大腿和内侧大腿的SAT厚度呈正相关，与女孩颈部的SAT厚度呈负相关。
总之，我们的研究描述了SAT地形对脂联素血清水平的影响，并提供了首个证据，即早期动脉粥样硬化与这种脂肪因子的低血清水平有关。
