Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria.
Obesity (Silver Spring). 2013 Jan;21(1):E71-7. doi: 10.1002/oby.20061. Epub 2013 Jan 29.
The obesity prevalence is growing worldwide and largely responsible for cardiovascular disease, the most common cause of death in the western world. The rationale of this study was to distinguish metabolically healthy from unhealthy overweight/obese young and adult patients as compared to healthy normal weight age matched controls by an extensive anthropometric, laboratory, and sonographic vascular assessment.
Three hundred fifty five young [8 to < 18 years, 299 overweight/obese(ow/ob), 56 normal weight (nw)] and 354 adult [>18-60 years, 175 (ow/ob), 179 nw)] participants of the STYJOBS/EDECTA (STYrian Juvenile Obesity Study/Early DEteCTion of Atherosclerosis) cohort were analyzed. STYJOBS/EDECTA (NCT00482924) is a crossectional study to investigate metabolic/cardiovascular risk profiles in normal and ow/ob people free of disease except metabolic syndrome (MetS).
From 299 young ow/ob subjects (8-< 18 years), 108 (36%), and from 175 adult ow/ob subjects (>18-60 years), 79 (45%) had positive criteria for MetS. In both age groups, prevalence of MetS was greater among males. Overweight/obese subjects were divided into "healthy" (no MetS criterion except anthropometry fulfilled) and "unhealthy" (MetS positive). Although percentage body fat did not differ between "healthy" and "unhealthy" ow/ob, nuchal and visceral fat were significantly greater in the "unhealthy" group which had also significantly higher values of carotid intima media thickness (IMT). With MetS as the dependent variable, two logistic regressions including juveniles <18 years or adults >18 years were performed. The potential predictor variables selected with the exception of age and gender by t test comparisons included IMT, ultrasensitive c-reactive protein (US-CRP), IL-6, malondialdehyde (MDA), oxidized LDL, leptin, adiponectin, uric acid (UA), aldosterone, cortisol, transaminases, fibrinogen. In both groups, uric acid and in adults only, leptin and adiponectin, turned out as the best predictor.
Serum levels of UA are a significant predictor of unhealthy obesity in juveniles and adults.
肥胖症在全球范围内日益普遍，是导致心血管疾病的主要原因，心血管疾病是西方世界最常见的死亡原因。本研究的目的是通过广泛的人体测量学、实验室和超声血管评估，将代谢健康与不健康的超重/肥胖年轻和成年患者与年龄匹配的健康正常体重对照组区分开来。
分析了 STYJOBS/EDECTA（STYrian Juvenile Obesity Study/Early DEteCTion of Atherosclerosis）队列的 355 名年轻参与者[8 岁至<18 岁，299 名超重/肥胖（ow/ob），56 名正常体重（nw）]和 354 名成年参与者[>18-60 岁，175 名（ow/ob），179 名 nw）]。STYJOBS/EDECTA（NCT00482924）是一项横断面研究，旨在调查除代谢综合征（MetS）外无疾病的正常和 ow/ob 人群的代谢/心血管风险特征。
在 299 名年轻的 ow/ob 受试者（8-<18 岁）中，有 108 名（36%），在 175 名成年 ow/ob 受试者（>18-60 岁）中，有 79 名（45%）符合 MetS 的阳性标准。在这两个年龄组中，男性的 MetS 患病率更高。超重/肥胖患者分为“健康”（除了人体测量学标准外，没有其他 MetS 标准符合）和“不健康”（MetS 阳性）。尽管“健康”和“不健康”ow/ob 之间的体脂百分比没有差异，但颈后和内脏脂肪在“不健康”组中明显更大，颈动脉内膜中层厚度（IMT）也明显更高。以 MetS 为因变量，对包括<18 岁的青少年或>18 岁的成年人进行了两次逻辑回归。通过 t 检验比较选择的潜在预测变量，除年龄和性别外，还包括 IMT、超敏 C 反应蛋白（US-CRP）、IL-6、丙二醛（MDA）、氧化 LDL、瘦素、脂联素、尿酸（UA）、醛固酮、皮质醇、转氨酶、纤维蛋白原。在这两个组中，尿酸和仅在成年人中，瘦素和脂联素是最佳预测因子。
血清 UA 水平是青少年和成年人不健康肥胖的重要预测因子。
