Turkoski Beatrice B
Advanced Practice Nursing, Kent State University College of Nursing, Kent, OH, USA.
Orthop Nurs. 2005 May-Jun;24(3):210-21; quiz 222-3. doi: 10.1097/00006416-200505000-00010.
In Part 1 of this three-part series, an overview of how antimicrobials, the "silver bullets" of modern medicine, are designed to target specific agents of infection was given. The worldwide concern regarding antimicrobial resistance and the need for a more judicious approach to using antimicrobials was addressed. In this section, the focus is on those specific antimicrobial agents used to fight bacterial infections. Discussion addresses bacterial cell wall inhibitors (penicillins and cephalosporins), protein synthesis inhibitors (macrolides, tetracyclines, and aminoglycosides), and nucleic acid inhibitors (sulfonamides and quinolones). Examples of agents in each class are identified, with a look at the specific use, action, and potential for adverse effects. A general overview of patient teaching for antibacterial use is included.
在这个三部分系列的第1部分中，概述了作为现代医学“银弹”的抗菌药物是如何设计以靶向特定感染病原体的。文中提到了全球对抗菌药物耐药性的关注以及更明智地使用抗菌药物的必要性。在本节中，重点是用于对抗细菌感染的那些特定抗菌药物。讨论内容包括细菌细胞壁抑制剂（青霉素和头孢菌素）、蛋白质合成抑制剂（大环内酯类、四环素类和氨基糖苷类）以及核酸抑制剂（磺胺类和喹诺酮类）。确定了每类药物的实例，并探讨了其具体用途、作用及潜在不良反应。还包括了关于抗菌药物使用的患者教育概述。
