Perlis Clifford S, Harwood Michael, Perlis Roy H
Department of Dermatology, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island, USA.
J Am Acad Dermatol. 2005 Jun;52(6):967-71. doi: 10.1016/j.jaad.2005.01.020.
Many published clinical trials are authored by investigators with financial conflicts of interest. The general medical literature documents the pervasive extent and sometimes problematic impact of these conflicts. Accordingly, there is renewed discussion about author disclosure and clinical trial registry to minimize publication bias from financial conflicts of interest. Despite this evolving discussion in the general medical literature, little is known about the extent or role of financial conflicts of interest in dermatology research.
Our purpose was to determine the extent and impact of industry sponsorship conflicts of interest in dermatology research.
We recorded potential financial conflicts of interest, study design, and study outcome in 179 clinical trials published between Oct 1, 2000 and Oct 1, 2003 in four leading dermatology journals.
Forty-three percent of analyzed studies included at least one author with a reported conflict of interest. These studies were more likely to report a positive result, demonstrate higher methodological quality, and include a larger sample size.
Conflict of interest in clinical investigations in dermatology appears to be prevalent and associated with potentially significant differences in study methodology and reporting.
许多已发表的临床试验由存在经济利益冲突的研究者撰写。普通医学文献记录了这些冲突的普遍程度以及有时产生的问题影响。因此，关于作者披露和临床试验注册以尽量减少经济利益冲突导致的发表偏倚的讨论再度兴起。尽管普通医学文献中的这一讨论不断发展，但对于皮肤科研究中经济利益冲突的程度或作用却知之甚少。
我们的目的是确定皮肤科研究中行业资助利益冲突的程度和影响。
我们记录了2000年10月1日至2003年10月1日期间在四种主要皮肤科期刊上发表的179项临床试验中的潜在经济利益冲突、研究设计和研究结果。
43%的分析研究至少有一位作者报告存在利益冲突。这些研究更有可能报告阳性结果，展示出更高的方法学质量，并且样本量更大。
皮肤科临床研究中的利益冲突似乎很普遍，并且与研究方法和报告方面可能存在的显著差异有关。
