1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold.
作者信息
Tong Yufeng, Buck Matthias
出版信息
J Biomol NMR. 2005 Apr;31(4):369-70. doi: 10.1007/s10858-005-0943-9.
Abstract
摘要
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1
1H, 15N and 13C Resonance assignments and secondary structure determination reveal that the minimal Rac1 GTPase binding domain of plexin-B1 has a ubiquitin fold.1H、15N和13C共振归属以及二级结构测定表明，丛状蛋白-B1的最小Rac1 GTP酶结合结构域具有泛素折叠。
J Biomol NMR. 2005 Apr;31(4):369-70. doi: 10.1007/s10858-005-0943-9.
2
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本文引用的文献
1
When monomers are preferred: a strategy for the identification and disruption of weakly oligomerized proteins.何时选择单体：一种鉴定和破坏弱寡聚化蛋白质的策略。
Structure. 2005 Jan;13(1):7-15. doi: 10.1016/j.str.2004.10.018.
2
Semaphorin junction: making tracks toward neural connectivity.信号素连接：迈向神经连接之路
Curr Opin Neurobiol. 2003 Feb;13(1):79-89. doi: 10.1016/s0959-4388(03)00003-5.
3
Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment.用于高通量蛋白质共振归属的降维核磁共振光谱法。
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8009-14. doi: 10.1073/pnas.122224599.
4
The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.丛状蛋白-B1/小G蛋白Rac相互作用抑制p21激活激酶（PAK）的激活，并增强信号素4D（Sema4D）配体结合。
Genes Dev. 2002 Apr 1;16(7):836-45. doi: 10.1101/gad.966402.
5
Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling.在果蝇中，丛状蛋白B通过同时抑制活性Rac并增强RhoA信号传导来介导轴突导向。
Neuron. 2001 Oct 11;32(1):39-51. doi: 10.1016/s0896-6273(01)00453-6.
6
Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.丛状蛋白B信号素受体直接与活性Rac相互作用，并通过激活Rho来调节肌动蛋白细胞骨架。
Curr Biol. 2001 Mar 6;11(5):339-44. doi: 10.1016/s0960-9822(01)00092-6.
7
The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner.信号素受体丛状蛋白-B1以配体依赖的方式与活性Rac特异性相互作用。
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457-62. doi: 10.1073/pnas.220421797.
8
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.在脊椎动物中，丛状蛋白是一类跨膜、分泌型和糖基磷脂酰肌醇锚定的信号素的大型受体家族。
Cell. 1999 Oct 1;99(1):71-80. doi: 10.1016/s0092-8674(00)80063-x.
9
The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data.13C化学位移指数：一种利用13C化学位移数据鉴定蛋白质二级结构的简单方法。
J Biomol NMR. 1994 Mar;4(2):171-80. doi: 10.1007/BF00175245.
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